Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) has been endemic in Italy since 2013. In a multicenter cohort study, we investigated various aspects of KPC-Kp among patients, including 15-day mortality rates and delays in adequate therapy. Most (77%) KPC-Kp strains were sequence types ST512 or ST307. During 2017, KPC-Kp prevalence was 3.26 cases/1,000 hospitalized patients. Cumulative incidence of KPC-Kp acquired >48 hours after hospital admission was 0.68% but varied widely between centers. Among patients with mild infections and noninfected colonized patients, 15-day mortality rates were comparable, but rates were much higher among patients with severe infections. Delays of >4 days in receiving adequate therapy more frequently occurred among patients with mild infections than those with severe infections, and delays were less common for patients with known previous KPC-Kp colonization. Italy urgently needs a concerted surveillance system to control the spread of KPC-Kp.

Rossi, M., Chatenoud, L., Gona, F., Sala, I., Nattino, G., D'Antonio, A., et al. (2021). Characteristics and Clinical Implications of Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection, Italy. EMERGING INFECTIOUS DISEASES, 27(5), 1416-1426 [10.3201/eid2705.203662].

Characteristics and Clinical Implications of Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection, Italy

Rossi, Marianna;Sala, Isabella;Bonfanti, Paolo;Puoti, Massimo;
2021

Abstract

Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) has been endemic in Italy since 2013. In a multicenter cohort study, we investigated various aspects of KPC-Kp among patients, including 15-day mortality rates and delays in adequate therapy. Most (77%) KPC-Kp strains were sequence types ST512 or ST307. During 2017, KPC-Kp prevalence was 3.26 cases/1,000 hospitalized patients. Cumulative incidence of KPC-Kp acquired >48 hours after hospital admission was 0.68% but varied widely between centers. Among patients with mild infections and noninfected colonized patients, 15-day mortality rates were comparable, but rates were much higher among patients with severe infections. Delays of >4 days in receiving adequate therapy more frequently occurred among patients with mild infections than those with severe infections, and delays were less common for patients with known previous KPC-Kp colonization. Italy urgently needs a concerted surveillance system to control the spread of KPC-Kp.
Articolo in rivista - Articolo scientifico
CRE; Carbapenem resistance; Enterobacteriaceae; Italy; KPC-Kp; Klebsiella pneumoniae; antimicrobial resistance; bacteria; healthcare-associated infections; mortality rates
English
2021
27
5
1416
1426
open
Rossi, M., Chatenoud, L., Gona, F., Sala, I., Nattino, G., D'Antonio, A., et al. (2021). Characteristics and Clinical Implications of Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection, Italy. EMERGING INFECTIOUS DISEASES, 27(5), 1416-1426 [10.3201/eid2705.203662].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/313598
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