BACKGROUND: although frailty and delirium are among the most frequent and burdensome geriatric syndromes, little is known about their association and impact on short-term mortality.OBJECTIVE: to examine, in hospitalized older persons, whether frailty is associated with delirium, and whether these two conditions, alone or in combination, affect these patients' 30-day survival.DESIGN: observational study nested in the Delirium Day project, with 30-day follow-up.SETTING: acute medical wards (n=118) and rehabilitation wards (n=46) in Italy.SUBJECTS: a total of 2,065 individuals aged 65+ years hospitalized in acute medical (1,484 patients, 71.9%) or rehabilitation (581 patients, 28.1%) wards.METHODS: a 25-item Frailty Index (FI) was created. Delirium was assessed using the 4AT test. Vital status was ascertained at 30days.RESULTS: overall, 469 (22.7%) patients experienced delirium on the index day and 82 (4.0%) died during follow-up. After adjustment for potential confounders, each FI score increase of 0.1 significantly increased the odds of delirium (odds ratio, OR: 1.66 [95% CI: 1.45-1.90]), with no difference between the acute (OR: 1.65 [95% CI: 1.41-1.93]) and rehabilitation ward patients (OR: 1.71 [95% CI: 1.27-2.30]). The risk of dying during follow-up also increased significantly for every FI increase of 0.1 in the overall population (OR: 1.65 [95% CI: 1.33-2.05]) and in the acute medical ward patients (OR: 1.61 [95% CI: 1.28-2.04]), but not in the rehabilitation patients. Delirium was not significantly associated with 30-day mortality in either hospital setting.CONCLUSIONS: in hospitalized older patients, frailty is associated with delirium and with an increased risk of short-term mortality.
Mazzola, P., Tassistro, E., Di Santo, S., Rossi, E., Andreano, A., Valsecchi, M., et al. (2021). The relationship between frailty and delirium: insights from the 2017 Delirium Day study. AGE AND AGEING.
|Citazione:||Mazzola, P., Tassistro, E., Di Santo, S., Rossi, E., Andreano, A., Valsecchi, M., et al. (2021). The relationship between frailty and delirium: insights from the 2017 Delirium Day study. AGE AND AGEING.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||The relationship between frailty and delirium: insights from the 2017 Delirium Day study|
|Autori:||Mazzola, P; Tassistro, E; Di Santo, S; Rossi, E; Andreano, A; Valsecchi, M; Cherubini, A; Marengoni, A; Mossello, E; Bo, M; Inzitari, M; Di Bari, M; Udina, C; Latronico, N; Paolillo, C; Morandi, A; Bellelli, G|
MAZZOLA, PAOLO (Primo)
TASSISTRO, ELENA (Secondo)
BELLELLI, GIUSEPPE (Ultimo) (Corresponding)
|Data di pubblicazione:||2021|
|Rivista:||AGE AND AGEING|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1093/ageing/afab042|
|Appare nelle tipologie:||01 - Articolo su rivista|