Subclinical inflammation has been associated with psychosis; however, it remains unknown whether this phenomenon appears also in the premorbid phase. Therefore, we performed a systematic review and meta-analysis of studies comparing peripheral blood levels of C-reactive protein (CRP) and cytokines between individuals at risk of psychosis and controls. Moreover, we tested the hypothesis that the levels of these markers may be different in high-risk converters versus non-converters. Two independent reviewers searched electronic databases until Dec 16th, 2020. After reviewing publication records, 16 studies (548 high-risk individuals and 559 controls) were included. Random-effects meta-analyses with Hedges’ g as the effect size estimate were performed. Individuals at clinical risk of psychosis had significantly higher levels of interleukin-6 (IL-6) compared to controls (g = 0.33, 95%CI: 0.06–0.60, p = 0.018). Heterogeneity was not significant in this subgroup analysis. Changes in the levels of IL-6 in subjects at familial risk of psychosis were not significant (g = 0.04, 95%CI: −0.24 to 0.31, p = 0.798). The use of antidepressants was associated with significantly higher levels of IL-6 in high-risk individuals (Beta = 1.56, 95%CI: 0.60–2.53, p = 0.001). No significant differences in the levels of immune-inflammatory markers were found between high-risk converters and non-converters. Our findings suggest that individuals at clinical risk of psychosis show subclinical inflammation in terms of elevated IL-6 levels. This phenomenon might be related to the use of antidepressants. The present meta-analysis does not support the usefulness of single immune-inflammatory markers in predicting transition to psychosis.
Misiak, B., Bartoli, F., Carra, G., Stanczykiewicz, B., Gladka, A., Frydecka, D., et al. (2021). Immune-inflammatory markers and psychosis risk: A systematic review and meta-analysis. PSYCHONEUROENDOCRINOLOGY, 127(May 2021).
|Citazione:||Misiak, B., Bartoli, F., Carra, G., Stanczykiewicz, B., Gladka, A., Frydecka, D., et al. (2021). Immune-inflammatory markers and psychosis risk: A systematic review and meta-analysis. PSYCHONEUROENDOCRINOLOGY, 127(May 2021).|
|Tipo:||Articolo in rivista - Review Essay|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||Immune-inflammatory markers and psychosis risk: A systematic review and meta-analysis|
|Autori:||Misiak, B; Bartoli, F; Carra, G; Stanczykiewicz, B; Gladka, A; Frydecka, D; Samochowiec, J; Jarosz, K; Hadrys, T; Miller, B|
|Data di pubblicazione:||2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.psyneuen.2021.105200|
|Appare nelle tipologie:||01 - Articolo su rivista|