The first-line chemotherapies for patients with unresectable pancreatic cancer (PC) are 5-fluorouracil (5-FU) and gemcitabine therapy. However, due to chemoresistance the prognosis of patients with PC has not been significantly improved. Mitochondria are essential organelles in eukaryotes that evolved from aerobic bacteria. In recent years, many studies have shown that mitochondria play important roles in tumorigenesis and may act as chemotherapeutic targets in PC. In addition, according to recent studies, mitochondria may play important roles in the chemoresistance of PC by affecting apoptosis, metabolism, mtDNA metabolism, and mitochondrial dynamics. Interfering with some of these factors in mitochondria may improve the sensitivity of PC cells to chemotherapeutic agents, such as gemcitabine, making mitochondria promising targets for overcoming chemoresistance in PC.

Fu, Y., Ricciardiello, F., Yang, G., Qiu, J., Huang, H., Xiao, J., et al. (2021). The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells. CELLS, 10(3 (25 February 2021)), 497-527 [10.3390/cells10030497].

The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells

Ricciardiello, Francesca
Co-primo
;
Chiaradonna, Ferdinando
;
2021

Abstract

The first-line chemotherapies for patients with unresectable pancreatic cancer (PC) are 5-fluorouracil (5-FU) and gemcitabine therapy. However, due to chemoresistance the prognosis of patients with PC has not been significantly improved. Mitochondria are essential organelles in eukaryotes that evolved from aerobic bacteria. In recent years, many studies have shown that mitochondria play important roles in tumorigenesis and may act as chemotherapeutic targets in PC. In addition, according to recent studies, mitochondria may play important roles in the chemoresistance of PC by affecting apoptosis, metabolism, mtDNA metabolism, and mitochondrial dynamics. Interfering with some of these factors in mitochondria may improve the sensitivity of PC cells to chemotherapeutic agents, such as gemcitabine, making mitochondria promising targets for overcoming chemoresistance in PC.
Si
Articolo in rivista - Articolo scientifico
Scientifica
apoptosis; chemoresistance; metabolism; mitochondria; pancreatic cancer;
English
Fu, Y., Ricciardiello, F., Yang, G., Qiu, J., Huang, H., Xiao, J., et al. (2021). The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells. CELLS, 10(3 (25 February 2021)), 497-527 [10.3390/cells10030497].
Fu, Y; Ricciardiello, F; Yang, G; Qiu, J; Huang, H; Xiao, J; Cao, Z; Zhao, F; Liu, Y; Luo, W; Chen, G; You, L; Chiaradonna, F; Zheng, L; Zhang, T
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/307769
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