Aims: Whether the association between uric acid (UA) and cardiovascular disease is influenced by some facilitating factors is unclear. The aim of this study was to investigate whether the risk of cardiovascular mortality (CVM) associated with elevated UA was modulated by the level of resting heart rate (HR). Methods and results: Multivariable Cox analyses were made in 19 128 participants from the multicentre Uric acid Right for heArt Health study. During a median follow-up of 11.2 years, there were 1381 cases of CVM. In multivariable Cox models both UA and HR, either considered as continuous or categorical variables were independent predictors of CVM both improving risk discrimination (P ≤ 0.003) and reclassification (P < 0.0001) over a multivariable model. However, the risk of CVM related to high UA (≥5.5 mg/dL, top tertile) was much lower in the subjects with HR

Palatini, P., Parati, G., Virdis, A., Reboldi, G., Masi, S., Mengozzi, A., et al. (2022). High heart rate amplifies the risk of cardiovascular mortality associated with elevated uric acid. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 29(11 (August 2022)), 1501-1509 [10.1093/eurjpc/zwab023].

High heart rate amplifies the risk of cardiovascular mortality associated with elevated uric acid

Parati, Gianfranco;Bombelli, Michele;Dell'Oro, Raffaella;Giannattasio, Cristina;Maloberti, Alessandro;Grassi, Guido;
2022

Abstract

Aims: Whether the association between uric acid (UA) and cardiovascular disease is influenced by some facilitating factors is unclear. The aim of this study was to investigate whether the risk of cardiovascular mortality (CVM) associated with elevated UA was modulated by the level of resting heart rate (HR). Methods and results: Multivariable Cox analyses were made in 19 128 participants from the multicentre Uric acid Right for heArt Health study. During a median follow-up of 11.2 years, there were 1381 cases of CVM. In multivariable Cox models both UA and HR, either considered as continuous or categorical variables were independent predictors of CVM both improving risk discrimination (P ≤ 0.003) and reclassification (P < 0.0001) over a multivariable model. However, the risk of CVM related to high UA (≥5.5 mg/dL, top tertile) was much lower in the subjects with HR
Articolo in rivista - Articolo scientifico
Cardiovascular; Heart rate; Longitudinal study; Mortality; Sympathetic activity; Uric acid;
English
14-feb-2021
2022
29
11 (August 2022)
1501
1509
none
Palatini, P., Parati, G., Virdis, A., Reboldi, G., Masi, S., Mengozzi, A., et al. (2022). High heart rate amplifies the risk of cardiovascular mortality associated with elevated uric acid. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 29(11 (August 2022)), 1501-1509 [10.1093/eurjpc/zwab023].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/306825
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