Background and aims: Deep repetitive Transcranial Magnetic Stimulation (deep rTMS) over the bilateral insula and prefrontal cortex (PFC) can promote weight-loss in obesity, preventing cardiometabolic complications as Type 2 Diabetes (T2D). To investigate the changes in the functional brain integration after dTMS, we conducted a resting-state functional connectivity (rsFC) study in obesity. Methods and results: This preliminary study was designed as a randomized, double-blind, sham-controlled study: 9 participants were treated with high-frequency stimulation (realTMS group), 8 were sham-treated (shamTMS group). Out of the 17 enrolled patients, 6 were affected by T2D. Resting-state fMRI scans were acquired at baseline (T0) and after the 5-week intervention (T1). Body weight was measured at three time points [T0, T1, 1-month follow-up visit (FU1)]. A mixed-model analysis showed a significant group-by-time interaction for body weight (p = .04), with a significant decrease (p < .001) in the realTMS group. The rsFC data revealed a significant increase of degree centrality for the realTMS group in the medial orbitofrontal cortex (mOFC) and a significant decrease in the occipital pole. Conclusion: An increase of whole-brain functional connections of the mOFC, together with the decrease of whole-brain functional connections with the occipital pole, may reflect a brain mechanism behind weight-loss through a diminished reactivity to bottom-up visual–sensory processes in favor of increased reliance on top-down decision-making processes. Trial registration number: ClinicalTrials.gov NCT03009695.

Devoto, F., Ferrulli, A., Zapparoli, L., Massarini, S., Banfi, G., Paulesu, E., et al. (2021). Repetitive deep TMS for the reduction of body weight: bimodal effect on the functional brain connectivity in “diabesity”. NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 31(6), 1860-1870 [10.1016/j.numecd.2021.02.015].

Repetitive deep TMS for the reduction of body weight: bimodal effect on the functional brain connectivity in “diabesity”

Devoto, Francantonio
Co-primo
;
Zapparoli, Laura
Secondo
;
Paulesu, Eraldo
Penultimo
;
2021

Abstract

Background and aims: Deep repetitive Transcranial Magnetic Stimulation (deep rTMS) over the bilateral insula and prefrontal cortex (PFC) can promote weight-loss in obesity, preventing cardiometabolic complications as Type 2 Diabetes (T2D). To investigate the changes in the functional brain integration after dTMS, we conducted a resting-state functional connectivity (rsFC) study in obesity. Methods and results: This preliminary study was designed as a randomized, double-blind, sham-controlled study: 9 participants were treated with high-frequency stimulation (realTMS group), 8 were sham-treated (shamTMS group). Out of the 17 enrolled patients, 6 were affected by T2D. Resting-state fMRI scans were acquired at baseline (T0) and after the 5-week intervention (T1). Body weight was measured at three time points [T0, T1, 1-month follow-up visit (FU1)]. A mixed-model analysis showed a significant group-by-time interaction for body weight (p = .04), with a significant decrease (p < .001) in the realTMS group. The rsFC data revealed a significant increase of degree centrality for the realTMS group in the medial orbitofrontal cortex (mOFC) and a significant decrease in the occipital pole. Conclusion: An increase of whole-brain functional connections of the mOFC, together with the decrease of whole-brain functional connections with the occipital pole, may reflect a brain mechanism behind weight-loss through a diminished reactivity to bottom-up visual–sensory processes in favor of increased reliance on top-down decision-making processes. Trial registration number: ClinicalTrials.gov NCT03009695.
Articolo in rivista - Articolo scientifico
Deep Transcranial Magnetic Stimulation; fMRI; Food craving; Functional connectivity; Obesity; Type 2 diabetes;
English
25-feb-2021
2021
31
6
1860
1870
none
Devoto, F., Ferrulli, A., Zapparoli, L., Massarini, S., Banfi, G., Paulesu, E., et al. (2021). Repetitive deep TMS for the reduction of body weight: bimodal effect on the functional brain connectivity in “diabesity”. NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 31(6), 1860-1870 [10.1016/j.numecd.2021.02.015].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/306725
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