The cost of HIV disease in Northern Italy: The payer's perspective

Background: Healthcare expenditures incurred by the Health Service for HIV-infected patients have not been reported in Italy. OBJECTIVE:: To present health care costs for HIV-infected patients in the Lombardy Region, in 2004-2007, to determine the clinical characteristics of HIV infection associated with costs. Methods: Retrospective, observational, budget impact study, based on information collected for the period 2004-2007, including hospitalizations, outpatient services, highly active antiretroviral therapy (HAART) and non-HAART drug utilization. Inclusion criteria includes: confirmed HIV infection, age 18 years, resident in Lombardy Region, and followed at the "L. Sacco" Hospital in Milan from 2004 to 2007. Results: The mean total cost per year to provide healthcare to HIV-positive patients was rather stable (€9658.36 in 2004 and €9745.65 in 2007 (+0.90%)); HAART represented more than 60% of the total cost. We found that hepatitis C virus coinfection was related to higher costs (€11,003.45 vs. €8896.06), as well as CD4 cell count <200 cells/mm (€12,681.36 vs. €9594.11 and €9450.36 in 200-499 and 500 cells/mm, respectively). The mean total cost of HIV health care was higher in patients who initiated antiretroviral treatment before 1997 than in those who started after 1996. Conclusions: The mean total cost per year to provide health care to HIV-positive patients was stable during the period 2004-2007, with an increase of HAART percentage impact on the total cost. Several clinical characteristics of HIV-infected patients were significantly associated with cost variation. © 2011 Lippincott Williams & Wilkins.