Central nervous system (CNS) symptoms have been reported in clinical trials and case reports in patients receiving raltegravir. We investigated CNS symptoms in 453 HIV-infected patients. Of these 47 (10.4%) developed at least one drug-related CNS symptom. Predictors of CNS symptoms were concomitant therapy with tenofovir or with proton pump inhibitors that can increase raltegravir concentration. Thus, our data suggest a possible correlation between high raltegravir plasma concentrations and CNS symptoms, and therefore their monitoring in clinical practice. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Madeddu, G., Menzaghi, B., Ricci, E., Carenzi, L., Martinelli, C., Di Biagio, A., et al. (2012). Raltegravir central nervous system tolerability in clinical practice: Results from a multicenter observational study. AIDS, 26(18), 2412-2415 [10.1097/QAD.0b013e32835aa141].

Raltegravir central nervous system tolerability in clinical practice: Results from a multicenter observational study

Bonfanti P.
2012

Abstract

Central nervous system (CNS) symptoms have been reported in clinical trials and case reports in patients receiving raltegravir. We investigated CNS symptoms in 453 HIV-infected patients. Of these 47 (10.4%) developed at least one drug-related CNS symptom. Predictors of CNS symptoms were concomitant therapy with tenofovir or with proton pump inhibitors that can increase raltegravir concentration. Thus, our data suggest a possible correlation between high raltegravir plasma concentrations and CNS symptoms, and therefore their monitoring in clinical practice. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Articolo in rivista - Articolo scientifico
Adenine; Anti-HIV Agents; Central Nervous System; Drug Administration Schedule; Drug Interactions; Female; HIV Infections; Humans; Male; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Tenofovir; Treatment Outcome; Viral Load;
English
2012
26
18
2412
2415
none
Madeddu, G., Menzaghi, B., Ricci, E., Carenzi, L., Martinelli, C., Di Biagio, A., et al. (2012). Raltegravir central nervous system tolerability in clinical practice: Results from a multicenter observational study. AIDS, 26(18), 2412-2415 [10.1097/QAD.0b013e32835aa141].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/305772
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