Pregnancy and Delivery Outcomes in Women with Persistent versus Resolved Low-lying Placenta in the Late Third Trimester

Objectives: The safest mode of delivery in low-lying placenta is debatable. Little is known about outcomes in low-lying placenta resolved during the late third trimester. We compare outcomes of women with persistent versus resolved low-lying placenta. Methods: A retrospective analysis on a prospective cohort of women with low-lying placenta confirmed at 28–30 weeks sonography (01/2009 to 03/2018). Women were followed up serially every 2 to 3 weeks until delivery to assess the placental edge-to-internal os distance (IOD), and included if scan was performed within 28 days before delivery. Results: There were 86 women: in 21 the low-lying placenta resolved, whereas in 65 persisted (n = 15 IOD 1–10 mm, n = 50 IOD 11–20 mm). Antepartum bleeding associated with higher rates of urgent cesarean delivery in 1–10 mm (P =.041) but not in 11–20 mm (P = 1.000) and >20 mm (P =.333). Among women with IOD >10 mm allowed to labor, vaginal delivery occurred in 76.7% (11–20 mm) and 94.1% (>20 mm) (P =.155), with no difference according to parity (70% and 80% in multiparas, P =.696; 60% and 72.7% in nulliparas, P =.698). Severe PPH (P =.922) and hemoglobin drop (P =.109) were similar among groups. Women with IOD 11–20 mm and >20 mm and vaginal delivery bled less than women with similarly located placenta and cesarean delivery (P =.009 and P =.048). Conclusions: Women with IOD >10 mm have high chances of deliver vaginally with no further increase of their hemorrhagic risk. Success of vaginal delivery is independent of parity and antepartum bleeding. Labor should be managed in an adequate hospital setting.