IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishBackground: Non-Hodgkin lymphoma (NHL) is the most common AIDS-defining condition in the era of antiretroviral therapy (ART). Whether chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection promote NHL in HIV-infected patients is unclear. Objective: To investigate whether chronic HBV and HCV infection are associated with increased incidence of NHL in HIVinfected patients. Design: Cohort study. Setting: 18 of 33 cohorts from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE). Patients: HIV-infected patients with information on HBV surface antigen measurements and detectable HCV RNA, or a positive HCV antibody test result if HCV RNA measurements were not available. Measurements: Time-dependent Cox models to assess risk for NHL in treatment-naive patients and those initiating ART, with inverse probability weighting to control for informative censoring. Results: A total of 52 479 treatment-naive patients (1339 [2.6%] with chronic HBV infection and 7506 [14.3%] with HCV infection) were included, of whom 40 219 (77%) later started ART. The median follow-up was 13 months for treatment-naive patients and 50 months for those receiving ART. A total of 252 treatmentnaive patients and 310 treated patients developed NHL, with incidence rates of 219 and 168 cases per 100 000 person-years, respectively. The hazard ratios for NHL with HBV and HCV infection were 1.33 (95% CI, 0.69 to 2.56) and 0.67 (CI, 0.40 to 1.12), respectively, in treatment-naive patients and 1.74 (CI, 1.08 to 2.82) and 1.73 (CI, 1.21 to 2.46), respectively, in treated patients. Limitation: Many treatment-naive patients later initiated ART, which limited the study of the associations of chronic HBV and HCV infection with NHL in this patient group. Conclusion: In HIV-infected patients receiving ART, chronic coinfection with HBV and HCV is associated with an increased risk for NHL.
Wang, Q., De Luca, A., Smith, C., Zangerle, R., Sambatakou, H., Bonnet, F., et al. (2017). Chronic hepatitis B and C virus infection and risk for non-hodgkin lymphoma in HIV-infected patients: A cohort study. ANNALS OF INTERNAL MEDICINE, 166(1), 9-17.
| Citazione: | Wang, Q., De Luca, A., Smith, C., Zangerle, R., Sambatakou, H., Bonnet, F., et al. (2017). Chronic hepatitis B and C virus infection and risk for non-hodgkin lymphoma in HIV-infected patients: A cohort study. ANNALS OF INTERNAL MEDICINE, 166(1), 9-17. |
| Titolo: | Chronic hepatitis B and C virus infection and risk for non-hodgkin lymphoma in HIV-infected patients: A cohort study |
| Tipo: | Articolo in rivista - Articolo scientifico |
| Presenza di un coautore afferente ad Istituzioni straniere: | Si |
| Carattere della pubblicazione: | Scientifica |
| Autori: | PUOTI, MASSIMO [Membro del Collaboration Group] |
| Data di pubblicazione: | 2017 |
| Autori: | Wang, Q; De Luca, A; Smith, C; Zangerle, R; Sambatakou, H; Bonnet, F; Smit, C; Schommers, P; Thornton, A; Berenguer, J; Peters, L; Spagnuolo, V; Ammassari, A; Antinori, A; Roldan, E; Mussini, C; Miro, J; Konopnicki, D; Fehr, J; Campbell, M; Termote, M; Bucher, H; Puoti, M |
| Numero degli autori: | 23 |
| Lingua: | English |
| Rivista: | ANNALS OF INTERNAL MEDICINE |
| Editore: | American College of Physicians |
| Revisione (peer review): | Esperti anonimi |
| Stato di pubblicazione: | Pubblicato |
| Volume: | 166 |
| Fascicolo: | 1 |
| Pagina iniziale: | 9 |
| Pagina finale: | 17 |
| Numero di pagine: | 9 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.7326/M16-0240 |
| Altre informazioni: | Puoti, M on behalf of The Hepatitis Coinfection and Non Hodgkin Lymphoma project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord |
| Full-text (pubblici): | none |
| Tipologia: | Articolo su rivista |
| Tipologia MIUR: | 262 |
| Codice identificativo Scopus: | 2-s2.0-85018225301 |
| Codice identificativo ISI: | WOS:000391467900004 |
| Codice identificativo Pubmed: | 27750294 |
| Abstract: | Background: Non-Hodgkin lymphoma (NHL) is the most common AIDS-defining condition in the era of antiretroviral therapy (ART). Whether chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection promote NHL in HIV-infected patients is unclear. Objective: To investigate whether chronic HBV and HCV infection are associated with increased incidence of NHL in HIVinfected patients. Design: Cohort study. Setting: 18 of 33 cohorts from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE). Patients: HIV-infected patients with information on HBV surface antigen measurements and detectable HCV RNA, or a positive HCV antibody test result if HCV RNA measurements were not available. Measurements: Time-dependent Cox models to assess risk for NHL in treatment-naive patients and those initiating ART, with inverse probability weighting to control for informative censoring. Results: A total of 52 479 treatment-naive patients (1339 [2.6%] with chronic HBV infection and 7506 [14.3%] with HCV infection) were included, of whom 40 219 (77%) later started ART. The median follow-up was 13 months for treatment-naive patients and 50 months for those receiving ART. A total of 252 treatmentnaive patients and 310 treated patients developed NHL, with incidence rates of 219 and 168 cases per 100 000 person-years, respectively. The hazard ratios for NHL with HBV and HCV infection were 1.33 (95% CI, 0.69 to 2.56) and 0.67 (CI, 0.40 to 1.12), respectively, in treatment-naive patients and 1.74 (CI, 1.08 to 2.82) and 1.73 (CI, 1.21 to 2.46), respectively, in treated patients. Limitation: Many treatment-naive patients later initiated ART, which limited the study of the associations of chronic HBV and HCV infection with NHL in this patient group. Conclusion: In HIV-infected patients receiving ART, chronic coinfection with HBV and HCV is associated with an increased risk for NHL. |
| Parole Chiave (Inglese): | HIV HCV NHL HBV |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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