Aim: The association between a blunted decrease in day-night heart rate and subclinical organ damage has not been investigated earlier in human hypertension. Therefore, we assessed such an association in a cohort of 658 untreated essential hypertensive patients. Methods: All patients underwent procedures including cardiac and carotid ultrasonography, 24-h urine collection for microalbuminuria, ambulatory blood pressure monitoring with simultaneous assessment of heart rate over two 24-h periods within 4 weeks. Nondipping heart rate was defined as a mean heart rate reduction at night lower than 10% compared with daytime values. Results: A reproducible nocturnal dipping (heart rate decrease >10% in both the ambulatory blood pressure monitoring periods) and nondipping profile was found in 513 (78%) and 76 patients (12%), respectively; 69 hypertensive patients (10%) had a variable dipping profile. The three groups did not differ with regard to age, sex, body size, metabolic variables, office and ambulatory blood pressures, left ventricular mass, carotid intima-media thickness, carotid plaque and microalbuminuria. In a univariate analysis, the decrease in nocturnal heart rate did not correlate with any parameter of subclinical organ damage. Conclusion: Our findings from a cross-sectional study do not support the view that a flattened heart rate circadian rhythm is related to a prevalent organ damage in essential hypertension and that this altered pattern is a marker for subclinical cardiovascular disease. The prognostic significance of this finding should be defined by prospective studies. Copyright © Lippincott Williams & Wilkins.

Cuspidi, C., Meani, S., Negri, F., Valerio, C., Sala, C., & Mancia, G. (2011). Is blunted heart rate decrease at night associated with prevalent organ damage in essential hypertension?. BLOOD PRESSURE MONITORING, 16(1), 16-21 [10.1097/MBP.0b013e32834331fe].

Is blunted heart rate decrease at night associated with prevalent organ damage in essential hypertension?

CUSPIDI, CESARE;NEGRI, FRANCESCA;MANCIA, GIUSEPPE
2011

Abstract

Aim: The association between a blunted decrease in day-night heart rate and subclinical organ damage has not been investigated earlier in human hypertension. Therefore, we assessed such an association in a cohort of 658 untreated essential hypertensive patients. Methods: All patients underwent procedures including cardiac and carotid ultrasonography, 24-h urine collection for microalbuminuria, ambulatory blood pressure monitoring with simultaneous assessment of heart rate over two 24-h periods within 4 weeks. Nondipping heart rate was defined as a mean heart rate reduction at night lower than 10% compared with daytime values. Results: A reproducible nocturnal dipping (heart rate decrease >10% in both the ambulatory blood pressure monitoring periods) and nondipping profile was found in 513 (78%) and 76 patients (12%), respectively; 69 hypertensive patients (10%) had a variable dipping profile. The three groups did not differ with regard to age, sex, body size, metabolic variables, office and ambulatory blood pressures, left ventricular mass, carotid intima-media thickness, carotid plaque and microalbuminuria. In a univariate analysis, the decrease in nocturnal heart rate did not correlate with any parameter of subclinical organ damage. Conclusion: Our findings from a cross-sectional study do not support the view that a flattened heart rate circadian rhythm is related to a prevalent organ damage in essential hypertension and that this altered pattern is a marker for subclinical cardiovascular disease. The prognostic significance of this finding should be defined by prospective studies. Copyright © Lippincott Williams & Wilkins.
Articolo in rivista - Articolo scientifico
heart rate diurnal variations
English
16
21
Cuspidi, C., Meani, S., Negri, F., Valerio, C., Sala, C., & Mancia, G. (2011). Is blunted heart rate decrease at night associated with prevalent organ damage in essential hypertension?. BLOOD PRESSURE MONITORING, 16(1), 16-21 [10.1097/MBP.0b013e32834331fe].
Cuspidi, C; Meani, S; Negri, F; Valerio, C; Sala, C; Mancia, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/30427
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