HYPOTHESIS: Perioperative administration of a supplemented enteral formula may decrease postoperative morbidity. DESIGN: Randomized clinical trial. SETTING: Department of surgery at a university hospital. PATIENTS: One hundred ninety-six registered malnourished patients (weight loss > or = 10%) who were candidates for major elective surgery for malignancy of the gastrointestinal tract. INTERVENTION: After randomization (n = 150), one group received postoperative enteral feeding with a standard diet within 12 hours of surgery (control group; n = 50). Another group orally received 1 L/d for 7 consecutive days of a liquid diet enriched with arginine, omega-3 fatty acids, and RNA (preoperative group; n = 50). After surgery, patients were given the same standard enteral formula as the control group. A third group orally received 1 L/d for 7 consecutive days of the enriched liquid diet. After surgery, patients were given enteral feeding with the same enriched formula (perioperative group; n = 50). MAIN OUTCOME MEASURES: Postoperative complications and length of hospital stay. RESULTS: The 3 groups were comparable for baseline demographics, biochemical markers, comorbidity factors, and surgical variables. The intent-to-treat analysis showed that the total number of patients with complications was 24 in the control group, 14 in the preoperative group, and 9 in the perioperative group (P =.02, control group vs perioperative group). Postoperative length of stay was significantly shorter in the preoperative (13.2 days) and perioperative (12.0 days) groups than in the control group (15.3 days) (P =.01 and P =.001, respectively, vs the control group). CONCLUSION: Perioperative immunonutrition seems to be the best approach to support malnourished patients with cancer.

Braga, M., Gianotti, L., Nespoli, L., Radaelli, G., Di Carlo, V. (2002). Nutritional approach in malnourished surgical patients: a prospective randomized study. ARCHIVES OF SURGERY, 137(2), 174-180.

Nutritional approach in malnourished surgical patients: a prospective randomized study

Braga, M;GIANOTTI, LUCA VITTORIO;NESPOLI, LUCA CARLO;
2002

Abstract

HYPOTHESIS: Perioperative administration of a supplemented enteral formula may decrease postoperative morbidity. DESIGN: Randomized clinical trial. SETTING: Department of surgery at a university hospital. PATIENTS: One hundred ninety-six registered malnourished patients (weight loss > or = 10%) who were candidates for major elective surgery for malignancy of the gastrointestinal tract. INTERVENTION: After randomization (n = 150), one group received postoperative enteral feeding with a standard diet within 12 hours of surgery (control group; n = 50). Another group orally received 1 L/d for 7 consecutive days of a liquid diet enriched with arginine, omega-3 fatty acids, and RNA (preoperative group; n = 50). After surgery, patients were given the same standard enteral formula as the control group. A third group orally received 1 L/d for 7 consecutive days of the enriched liquid diet. After surgery, patients were given enteral feeding with the same enriched formula (perioperative group; n = 50). MAIN OUTCOME MEASURES: Postoperative complications and length of hospital stay. RESULTS: The 3 groups were comparable for baseline demographics, biochemical markers, comorbidity factors, and surgical variables. The intent-to-treat analysis showed that the total number of patients with complications was 24 in the control group, 14 in the preoperative group, and 9 in the perioperative group (P =.02, control group vs perioperative group). Postoperative length of stay was significantly shorter in the preoperative (13.2 days) and perioperative (12.0 days) groups than in the control group (15.3 days) (P =.01 and P =.001, respectively, vs the control group). CONCLUSION: Perioperative immunonutrition seems to be the best approach to support malnourished patients with cancer.
Articolo in rivista - Articolo scientifico
Food, Formulated; Treatment Outcome; Enteral Nutrition; Gastrointestinal Neoplasms; Male; RNA; Female; Nutrition Disorders; Chi-Square Distribution; Risk Factors; Italy; Arginine; Humans; Prospective Studies; Administration, Oral; Postoperative Care; Postoperative Complications; Fatty Acids, Omega-3; Incidence; Length of Stay
English
2002
137
2
174
180
none
Braga, M., Gianotti, L., Nespoli, L., Radaelli, G., Di Carlo, V. (2002). Nutritional approach in malnourished surgical patients: a prospective randomized study. ARCHIVES OF SURGERY, 137(2), 174-180.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/30354
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