Rehabilitative exercise outcomes and plasma concentrations of soluble adhesion molecules (sEndoglin, sE-Selectin, sL-Selectin, sICAM-1, sNCAM, sNCAM-1, sVCAM-1, sPECAM-1, sVAP-1) were evaluated in 60 severely disabled progressive multiple sclerosis (MS) patients at 4-time points. Changes of sE-Selectin, sL-Selectin, and sPECAM-1 concentrations were observed over time, and their variations were significantly correlated with rehabilitative outcome variations. Baseline sVAP-1 concentrations were able to predict functional mobility recovery. Our data suggest that the evaluation of adhesion molecules in plasma provides useful information to interpret rehabilitative exercise processes and to identify potential predictors of the rehabilitation-induced changes in mobility outcomes in MS patients.

Ziliotto, N., Lamberti, N., Manfredini, F., Straudi, S., Tisato, V., Carantoni, M., et al. (2021). Baseline and overtime variations of soluble adhesion molecule plasma concentrations are associated with mobility recovery after rehabilitation in multiple sclerosis patients. JOURNAL OF NEUROIMMUNOLOGY, 352(15 March 2021) [10.1016/j.jneuroim.2020.577473].

Baseline and overtime variations of soluble adhesion molecule plasma concentrations are associated with mobility recovery after rehabilitation in multiple sclerosis patients

Ziliotto N.;
2021

Abstract

Rehabilitative exercise outcomes and plasma concentrations of soluble adhesion molecules (sEndoglin, sE-Selectin, sL-Selectin, sICAM-1, sNCAM, sNCAM-1, sVCAM-1, sPECAM-1, sVAP-1) were evaluated in 60 severely disabled progressive multiple sclerosis (MS) patients at 4-time points. Changes of sE-Selectin, sL-Selectin, and sPECAM-1 concentrations were observed over time, and their variations were significantly correlated with rehabilitative outcome variations. Baseline sVAP-1 concentrations were able to predict functional mobility recovery. Our data suggest that the evaluation of adhesion molecules in plasma provides useful information to interpret rehabilitative exercise processes and to identify potential predictors of the rehabilitation-induced changes in mobility outcomes in MS patients.
Articolo in rivista - Articolo scientifico
Adhesion molecules; Multiple sclerosis; Rehabilitative exercise; Selectins; VAP-1;
English
2-gen-2021
2021
352
15 March 2021
577473
none
Ziliotto, N., Lamberti, N., Manfredini, F., Straudi, S., Tisato, V., Carantoni, M., et al. (2021). Baseline and overtime variations of soluble adhesion molecule plasma concentrations are associated with mobility recovery after rehabilitation in multiple sclerosis patients. JOURNAL OF NEUROIMMUNOLOGY, 352(15 March 2021) [10.1016/j.jneuroim.2020.577473].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/302378
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