Lambda interferons (IFNλs, type III IFNs or interleukins-28/29) were described fifteen years ago as novel cytokines sharing structural and functional homology with IL-10 and type I IFNs, respectively. IFNλs engage a unique receptor complex comprising IFNLR1 and IL10R2, nevertheless they share signaling cascade and many functions with type I IFNs, questioning their possible non-redundant roles and overall biological importance. Here, we review the latest evidence establishing the primacy of IFNλs in front line protection at anatomical barriers, mediating antiviral immunity before type I IFNs. We also discuss their emerging role in regulating inflammation and limiting host damage, a major difference to type I IFNs. IFNλs come thus to light as dual function cytokines mediating antiviral immunity and damage control.

Andreakos, E., Zanoni, I., Galani, I. (2019). Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control. CURRENT OPINION IN IMMUNOLOGY, 56, 67-75 [10.1016/j.coi.2018.10.007].

Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control

Zanoni I.;
2019

Abstract

Lambda interferons (IFNλs, type III IFNs or interleukins-28/29) were described fifteen years ago as novel cytokines sharing structural and functional homology with IL-10 and type I IFNs, respectively. IFNλs engage a unique receptor complex comprising IFNLR1 and IL10R2, nevertheless they share signaling cascade and many functions with type I IFNs, questioning their possible non-redundant roles and overall biological importance. Here, we review the latest evidence establishing the primacy of IFNλs in front line protection at anatomical barriers, mediating antiviral immunity before type I IFNs. We also discuss their emerging role in regulating inflammation and limiting host damage, a major difference to type I IFNs. IFNλs come thus to light as dual function cytokines mediating antiviral immunity and damage control.
Articolo in rivista - Review Essay
immunoglobulin enhancer binding protein; antimicrobial activity; Antiviral Agents;
English
3-nov-2018
2019
56
67
75
reserved
Andreakos, E., Zanoni, I., Galani, I. (2019). Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control. CURRENT OPINION IN IMMUNOLOGY, 56, 67-75 [10.1016/j.coi.2018.10.007].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/302297
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