Researchers worldwide are taking advantage of novel, commercially available, technologies, such as ion mobility mass spectrometry (IM-MS), for metabolomics and lipidomics applications in a variety of fields including life, biomedical, and food sciences. IM-MS provides three main technical advantages over traditional LC-MS workflows. Firstly, in addition to mass, IM-MS allows collision cross-section values to be measured for metabolites and lipids, a physicochemical identifier related to the chemical shape of an analyte that increases the confidence of identification. Second, IM-MS increases peak capacity and the signal-to-noise, improving fingerprinting as well as quantification, and better defining the spatial localization of metabolites and lipids in biological and food samples. Third, IM-MS can be coupled with various fragmentation modes, adding new tools to improve structural characterization and molecular annotation. Here, we review the state-of-the-art in IM-MS technologies and approaches utilized to support metabolomics and lipidomics applications and we assess the challenges and opportunities in this growing field.
Paglia, G., Smith, A., & Astarita, G. (2021). Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics. MASS SPECTROMETRY REVIEWS.
|Citazione:||Paglia, G., Smith, A., & Astarita, G. (2021). Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics. MASS SPECTROMETRY REVIEWS.|
|Tipo:||Articolo in rivista - Review Essay|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics|
|Autori:||Paglia, G; Smith, A; Astarita, G|
PAGLIA, GIUSEPPE (Primo)
|Data di pubblicazione:||2021|
|Rivista:||MASS SPECTROMETRY REVIEWS|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/mas.21686|
|Appare nelle tipologie:||01 - Articolo su rivista|