Neuroinflammation is a highly reactive response that has not been addressed due to its complexity. Some of its molecular pathways, such as glycosylation, have been neglected in the past. Despite the intricacy and diversity of the glycome, there has been an increased interest in this field of study, which has resulted in fostering advances in glycobiology and glycochemistry. These advances have supported the emergence of a new class of glyco-engineered approaches, in which biomaterial-based strategies can address different disease glycophenotypes. Even though these are not extensively used yet, this review aims to provide a resourceful toolbox to build a wide variety of novel materials that can be designed to tackle the glyco-dysregulations seen in neuroinflammation. By assembling the already-well-described knowledge from glycobiology and chemistry, the best of both worlds can be harnessed toward the emergence of a new biomaterial science branch of study: polymeric-based glyco-modulatory materials.

Rebelo, A., Chevalier, M., Russo, L., Pandit, A. (2021). Sweet tailoring of glyco-modulatory extracellular matrix-inspired biomaterials to target neuroinflammation. CELL REPORTS PHYSICAL SCIENCE, 2(2 (24 February 2021)) [10.1016/j.xcrp.2021.100321].

Sweet tailoring of glyco-modulatory extracellular matrix-inspired biomaterials to target neuroinflammation

Russo, Laura;
2021

Abstract

Neuroinflammation is a highly reactive response that has not been addressed due to its complexity. Some of its molecular pathways, such as glycosylation, have been neglected in the past. Despite the intricacy and diversity of the glycome, there has been an increased interest in this field of study, which has resulted in fostering advances in glycobiology and glycochemistry. These advances have supported the emergence of a new class of glyco-engineered approaches, in which biomaterial-based strategies can address different disease glycophenotypes. Even though these are not extensively used yet, this review aims to provide a resourceful toolbox to build a wide variety of novel materials that can be designed to tackle the glyco-dysregulations seen in neuroinflammation. By assembling the already-well-described knowledge from glycobiology and chemistry, the best of both worlds can be harnessed toward the emergence of a new biomaterial science branch of study: polymeric-based glyco-modulatory materials.
Articolo in rivista - Review Essay
carbohydrates; central nervous system; extracellular matrix; glycan-functionalization; glycans; glycobiology; glycochemistry; glycosylation profile; neuroinflammation; sugars;
English
25-gen-2021
2021
2
2 (24 February 2021)
100321
none
Rebelo, A., Chevalier, M., Russo, L., Pandit, A. (2021). Sweet tailoring of glyco-modulatory extracellular matrix-inspired biomaterials to target neuroinflammation. CELL REPORTS PHYSICAL SCIENCE, 2(2 (24 February 2021)) [10.1016/j.xcrp.2021.100321].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/300962
Citazioni
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 8
Social impact