Peripheral blood lymphocytes (PBL) from 43 patients with histologically confirmed ovarian carcinoma were stimulated in mixed lymphocyte-tumor culture (MLTC) with purified autologous tumor cells. Positive results, assessed as lymphocyte proliferation, were observed in 21 cases (48.8%). Lymphoid cells associated with ascitic fluid or infiltrating solid masses were in general less reactive than PBL as only 3/11 cases had positive MLTC. Tumor cells isolated from peritoneal effusions showed no significant difference in stimulatory potential as compared to the primary tumor. These results suggest that in an appreciable proportion of ovarian carcinoma patients (approximately 50%), lymphocytes have the potential to react to autologous tumor cells. Comprehension of the immunological mechanisms of antitumor resistance may have direct practical relevance for more effective treatment of neoplasms.

Allavena, P., Lo Presti, P., Di Bello, M., Lucchini, V., Lissoni, A., Zanetta, G., et al. (1988). Proliferative response of lymphocytes from ovarian cancer patients to autologous tumor cells. CANCER IMMUNOLOGY, IMMUNOTHERAPY, 27(1), 69-76.

Proliferative response of lymphocytes from ovarian cancer patients to autologous tumor cells

LISSONI, ANDREA ALBERTO;
1988

Abstract

Peripheral blood lymphocytes (PBL) from 43 patients with histologically confirmed ovarian carcinoma were stimulated in mixed lymphocyte-tumor culture (MLTC) with purified autologous tumor cells. Positive results, assessed as lymphocyte proliferation, were observed in 21 cases (48.8%). Lymphoid cells associated with ascitic fluid or infiltrating solid masses were in general less reactive than PBL as only 3/11 cases had positive MLTC. Tumor cells isolated from peritoneal effusions showed no significant difference in stimulatory potential as compared to the primary tumor. These results suggest that in an appreciable proportion of ovarian carcinoma patients (approximately 50%), lymphocytes have the potential to react to autologous tumor cells. Comprehension of the immunological mechanisms of antitumor resistance may have direct practical relevance for more effective treatment of neoplasms.
Articolo in rivista - Articolo scientifico
Carcinoma; Ascitic Fluid; Ovarian Neoplasms; Middle Aged; Lymphocyte Activation; Female; Aged; Lymphocyte Culture Test, Mixed; Adult; Cell Separation; Lymphocytes; Humans
English
69
76
Allavena, P., Lo Presti, P., Di Bello, M., Lucchini, V., Lissoni, A., Zanetta, G., et al. (1988). Proliferative response of lymphocytes from ovarian cancer patients to autologous tumor cells. CANCER IMMUNOLOGY, IMMUNOTHERAPY, 27(1), 69-76.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/30065
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