OBJECTIVE: In order to provide an updated quantification of the association between alcohol drinking and epithelial ovarian cancer risk, we conducted a meta-analysis of published observational studies. METHODS: Using PubMed, we performed a literature search of all case-control and cohort studies published as original articles in English up to September 2011. We included 27 observational studies, of which 23 were case-control studies, 3 cohort studies and one pooled analysis of prospective cohort studies, including a total of 16,554 epithelial ovarian cancer cases. We derived pooled meta-analytic estimates using random-effects models. RESULTS: The pooled relative risk (RR) for any alcohol drinking compared with non/occasional drinking was 1.00 [95% confidence interval (CI), 0.95-1.05]. The RRs were 0.97 (95% CI, 0.92-1.02), 1.03 (95% CI, 0.96-1.11) and 1.09 (95% CI, 0.80-1.50) for light (≤1drink/day), moderate (>1 to <3 drinks) and heavy drinking (≥3drinks/day), respectively. In particular, pooled RR for invasive epithelial ovarian cancers was 1.00 (95% CI, 0.95-1.06), while for borderline cancers was 0.96 (95% CI, 0.74-1.26). Stratified analyses across cancer histotypes revealed a modest protective effect of alcohol on endometrioid epithelial ovarian tumors (RR=0.82, 95% CI, 0.70-0.96), while no association was found for serous (RR=1.00, 95% CI, 0.84-1.19), mucinous (RR=0.91, 95% CI, 0.78-1.08) and clear cell (RR=0.93, 95% CI, 0.76-1.14) cancers. There was no evidence of publication bias. CONCLUSIONS: This comprehensive meta-analysis provided no evidence of a material association between alcohol drinking and epithelial ovarian cancer risk.

Rota, M., Pasquali, E., Scotti, L., Pelucchi, C., Tramacere, I., Islami, F., et al. (2012). Alcohol drinking and epithelial ovarian cancer risk. A systematic review and meta-analysis. GYNECOLOGIC ONCOLOGY, 125(3), 758-763 [10.1016/j.ygyno.2012.03.031].

Alcohol drinking and epithelial ovarian cancer risk. A systematic review and meta-analysis

ROTA, MATTEO
;
SCOTTI, LORENZA;BELLOCCO, RINO;CORRAO, GIOVANNI;BAGNARDI, VINCENZO
Ultimo
2012

Abstract

OBJECTIVE: In order to provide an updated quantification of the association between alcohol drinking and epithelial ovarian cancer risk, we conducted a meta-analysis of published observational studies. METHODS: Using PubMed, we performed a literature search of all case-control and cohort studies published as original articles in English up to September 2011. We included 27 observational studies, of which 23 were case-control studies, 3 cohort studies and one pooled analysis of prospective cohort studies, including a total of 16,554 epithelial ovarian cancer cases. We derived pooled meta-analytic estimates using random-effects models. RESULTS: The pooled relative risk (RR) for any alcohol drinking compared with non/occasional drinking was 1.00 [95% confidence interval (CI), 0.95-1.05]. The RRs were 0.97 (95% CI, 0.92-1.02), 1.03 (95% CI, 0.96-1.11) and 1.09 (95% CI, 0.80-1.50) for light (≤1drink/day), moderate (>1 to <3 drinks) and heavy drinking (≥3drinks/day), respectively. In particular, pooled RR for invasive epithelial ovarian cancers was 1.00 (95% CI, 0.95-1.06), while for borderline cancers was 0.96 (95% CI, 0.74-1.26). Stratified analyses across cancer histotypes revealed a modest protective effect of alcohol on endometrioid epithelial ovarian tumors (RR=0.82, 95% CI, 0.70-0.96), while no association was found for serous (RR=1.00, 95% CI, 0.84-1.19), mucinous (RR=0.91, 95% CI, 0.78-1.08) and clear cell (RR=0.93, 95% CI, 0.76-1.14) cancers. There was no evidence of publication bias. CONCLUSIONS: This comprehensive meta-analysis provided no evidence of a material association between alcohol drinking and epithelial ovarian cancer risk.
Articolo in rivista - Articolo scientifico
Alcohol-drinking; Dose–risk relation; Meta-analysis; Epithelial ovarian cancer
English
758
763
6
Rota, M., Pasquali, E., Scotti, L., Pelucchi, C., Tramacere, I., Islami, F., et al. (2012). Alcohol drinking and epithelial ovarian cancer risk. A systematic review and meta-analysis. GYNECOLOGIC ONCOLOGY, 125(3), 758-763 [10.1016/j.ygyno.2012.03.031].
Rota, M; Pasquali, E; Scotti, L; Pelucchi, C; Tramacere, I; Islami, F; Negri, E; Boffetta, P; Bellocco, R; Corrao, G; La Vecchia, C; Bagnardi, V
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/30016
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