Stem cells in brain niches are responsible for neurogenesis and integration of new neurons into functional circuits, with inflammatory and immune system mediators playing critical roles in neurogenesis and in several diseases of the nervous system. TLR4 is known to be a master player in the development of neuroinflammation processes and to be upregulated in several animal models of neurodegenerative disorders like amyotrophic lateral sclerosis (ALS). Nonetheless, Toll-like receptor 4 (TLR4) also plays a key role in CNS homeostasis. TLR4 is expressed in microglia, which is a master player in neuroinflammatory processes, as well as in neural cells: astrocytes, neurons, oligodendrocytes, neural progenitors (NPCs), and neural stem cells (NSCs). Here we discuss the dual role of TLR4 in brain homeostasis, suggesting that, in a translational perspective, TLR4-mediated regulation of human neural stem cells (hNSCs) needs to be deeply investigated either for the identification of novel biomarkers for rare diseases or future therapeutic approaches of aging and neurodegenerative disorders.

(2020). The Role of TLR4 in Neural Stem Cells–Mediated Neurogenesis and Neuroinflammation. In The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation (pp. 129-141). Birkhaeuser Science [10.1007/978-3-030-56319-6_9].

The Role of TLR4 in Neural Stem Cells–Mediated Neurogenesis and Neuroinflammation

De Filippis, Lidia
;
Peri, Francesco
2020

Abstract

Stem cells in brain niches are responsible for neurogenesis and integration of new neurons into functional circuits, with inflammatory and immune system mediators playing critical roles in neurogenesis and in several diseases of the nervous system. TLR4 is known to be a master player in the development of neuroinflammation processes and to be upregulated in several animal models of neurodegenerative disorders like amyotrophic lateral sclerosis (ALS). Nonetheless, Toll-like receptor 4 (TLR4) also plays a key role in CNS homeostasis. TLR4 is expressed in microglia, which is a master player in neuroinflammatory processes, as well as in neural cells: astrocytes, neurons, oligodendrocytes, neural progenitors (NPCs), and neural stem cells (NSCs). Here we discuss the dual role of TLR4 in brain homeostasis, suggesting that, in a translational perspective, TLR4-mediated regulation of human neural stem cells (hNSCs) needs to be deeply investigated either for the identification of novel biomarkers for rare diseases or future therapeutic approaches of aging and neurodegenerative disorders.
Si
Scientifica
Capitolo o saggio
Neural stem cells (NSC); Neurogenesis; Neuroinflammation; TLR4;
English
The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation
978-3-030-56318-9
Softcover ISBN 978-3-030-56321-9 - eBook ISBN 978-3-030-56319-6
(2020). The Role of TLR4 in Neural Stem Cells–Mediated Neurogenesis and Neuroinflammation. In The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation (pp. 129-141). Birkhaeuser Science [10.1007/978-3-030-56319-6_9].
De Filippis, L; Peri, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/300128
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