Several lines of evidence suggest that childhood leukemia, the most common cancer in young age, originates during in utero development. However, our knowledge of the cellular origin of this large and heterogeneous group of malignancies is still incomplete. The identification and characterization of their cell of origin is of crucial importance in order to define the processes that initiate and sustain disease progression, to refine faithful animal models and to identify novel therapeutic approaches. During embryogenesis, hematopoiesis takes place at different anatomical sites in sequential waves, and occurs in both a hematopoietic stem cell (HSC)-dependent and a HSC-independent fashion. Despite the recently described relevance and complexity of HSC-independent hematopoiesis, few studies have so far investigated its potential involvement in leukemogenesis. Here, we review the current knowledge on prenatal origin of leukemias in the context of recent insights in developmental hematopoiesis.

Cazzola, A., Cazzaniga, G., Biondi, A., Meneveri, R., Brunelli, S., & Azzoni, E. (2021). Prenatal Origin of Pediatric Leukemia: Lessons From Hematopoietic Development. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 8 [10.3389/fcell.2020.618164].

Prenatal Origin of Pediatric Leukemia: Lessons From Hematopoietic Development

Cazzola, Anna
Primo
;
Cazzaniga, Giovanni;Biondi, Andrea;Meneveri, Raffaella;Brunelli, Silvia;Azzoni, Emanuele
Ultimo
2021

Abstract

Several lines of evidence suggest that childhood leukemia, the most common cancer in young age, originates during in utero development. However, our knowledge of the cellular origin of this large and heterogeneous group of malignancies is still incomplete. The identification and characterization of their cell of origin is of crucial importance in order to define the processes that initiate and sustain disease progression, to refine faithful animal models and to identify novel therapeutic approaches. During embryogenesis, hematopoiesis takes place at different anatomical sites in sequential waves, and occurs in both a hematopoietic stem cell (HSC)-dependent and a HSC-independent fashion. Despite the recently described relevance and complexity of HSC-independent hematopoiesis, few studies have so far investigated its potential involvement in leukemogenesis. Here, we review the current knowledge on prenatal origin of leukemias in the context of recent insights in developmental hematopoiesis.
Articolo in rivista - Review Essay
Scientifica
cell of origin; eryhtro-myeloid progenitors; hematopoiesis; hematopoietic stem cells; pediatric leukemia;
English
Cazzola, A., Cazzaniga, G., Biondi, A., Meneveri, R., Brunelli, S., & Azzoni, E. (2021). Prenatal Origin of Pediatric Leukemia: Lessons From Hematopoietic Development. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 8 [10.3389/fcell.2020.618164].
Cazzola, A; Cazzaniga, G; Biondi, A; Meneveri, R; Brunelli, S; Azzoni, E
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/299006
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