Numerous lines of evidence have shown that the interaction between the nuclear and mitochondrial genomes ensures the efficient functioning of the OXPHOS complexes, with substantial implications in bioenergetics, adaptation, and disease. Their interaction is a fascinating and complex trait of the eukaryotic cell that MitImpact explores with its third major release. MitImpact expands its collection of genomic, clinical, and functional annotations of all non-synonymous substitutions of the human mitochondrial genome with new information on putative Compensated Pathogenic Deviations and co-varying amino acid sites of the Respiratory Chain subunits. It further provides evidence of energetic and structural residue compensation by techniques of molecular dynamics simulation. MitImpact is freely accessible at http://mitimpact.css-mendel.it.

Castellana, S., Biagini, T., Petrizzelli, F., Parca, L., Panzironi, N., Caputo, V., et al. (2021). MitImpact 3: modeling the residue interaction network of the Respiratory Chain subunits. NUCLEIC ACIDS RESEARCH, 49(D1), D1282-D1288 [10.1093/nar/gkaa1032].

MitImpact 3: modeling the residue interaction network of the Respiratory Chain subunits

Vescovi, Angelo Luigi;
2021

Abstract

Numerous lines of evidence have shown that the interaction between the nuclear and mitochondrial genomes ensures the efficient functioning of the OXPHOS complexes, with substantial implications in bioenergetics, adaptation, and disease. Their interaction is a fascinating and complex trait of the eukaryotic cell that MitImpact explores with its third major release. MitImpact expands its collection of genomic, clinical, and functional annotations of all non-synonymous substitutions of the human mitochondrial genome with new information on putative Compensated Pathogenic Deviations and co-varying amino acid sites of the Respiratory Chain subunits. It further provides evidence of energetic and structural residue compensation by techniques of molecular dynamics simulation. MitImpact is freely accessible at http://mitimpact.css-mendel.it.
Articolo in rivista - Articolo scientifico
OXPHOS complexes, nuclear and mitochondrial genomes, MitImpact;
English
9-dic-2020
2021
49
D1
D1282
D1288
none
Castellana, S., Biagini, T., Petrizzelli, F., Parca, L., Panzironi, N., Caputo, V., et al. (2021). MitImpact 3: modeling the residue interaction network of the Respiratory Chain subunits. NUCLEIC ACIDS RESEARCH, 49(D1), D1282-D1288 [10.1093/nar/gkaa1032].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/298763
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