The relationship between hepatic tolerance and hepatitis C virus (HCV) co-infection has not been extensively studied in clinical practice. We assessed the efficacy and safety of raltegravir-based therapy in an Italian cohort of HIV/HCV co-infected patients. One hundred and forty patients with HIV/HCV co-infection initiating raltegravir from SCOLTA project (Surveillance Cohort Long-Term Toxicity Antiretrovirals) were examined. Of them, 43 were women, with mean age of 45.4. ±. 6.4. years; 65 (46%) had undetectable HIV-RNA. < 50. copies/mL and 75 (54%) HIV-RNA. ≥. 50. copies/mL. According to CDC classification, 49 (35%) were in stage C. Based on Fib4 score at the time of starting raltegravir, patients were classified in class I in 41 cases, class II in 68 and in class III in 31 cases. Globally, the Fib4 score slightly decreased during 24. months follow-up, from 2.2 to a value of 1.8. Hepatic adverse events of any grade were observed in 67 patients, of which only 2 cases (3%) had severe liver toxicity (grade 3-4). Only one patient had to discontinue the therapy because of adverse events. According to univariate analysis, being in CDC stage C represented a risk for the development of liver toxicity, with a hazard ratio (HR) of 2.27 (95% CI 1.06-4.84, P= 0.033). None of the other variables considered (age, sex, years since detection of HIV and HCV-RNA detectable, years of previous HIV therapy, concomitant therapy with PI or NRTI, CD4+ cell count, Fib4, and transaminases level at baseline) resulted statistically correlated to the outcome. In conclusion, raltegravir-based regimens can be safely used in HCV infected patients; in this study, the hepatic toxicity has been found to be more frequent in patients with an advanced HIV disease (CDC stage C), independently of HIV-RNA suppression at raltegravir initiation.
Taramasso, L., Madeddu, G., Ricci, E., De Socio, G., Menzaghi, B., Orofino, G., et al. (2015). Raltegravir-based therapy in a cohort of HIV/HCV co-infected individuals. BIOMÉDECINE & PHARMACOTHÉRAPIE, 69, 233-236.
|Citazione:||Taramasso, L., Madeddu, G., Ricci, E., De Socio, G., Menzaghi, B., Orofino, G., et al. (2015). Raltegravir-based therapy in a cohort of HIV/HCV co-infected individuals. BIOMÉDECINE & PHARMACOTHÉRAPIE, 69, 233-236.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||Raltegravir-based therapy in a cohort of HIV/HCV co-infected individuals|
|Autori:||Taramasso, L; Madeddu, G; Ricci, E; De Socio, G; Menzaghi, B; Orofino, G; Passerini, S; Franzetti, M; Maggi, P; Dentone, C; Martinelli, C; Celesia, B; Penco, G; Libertone, R; Quirino, T; Bonfanti, P; Di Biagio, A|
|Data di pubblicazione:||2015|
|Rivista:||BIOMÉDECINE & PHARMACOTHÉRAPIE|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.biopha.2014.12.006|
|Appare nelle tipologie:||01 - Articolo su rivista|