Background: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. We aimed to assess left atrial (LA) function by two-dimensional speckle tracking echocardiography and its relation with left ventricular (LV) function and clinical status in patients with HCM. Methods: We prospectively enrolled 37 consecutive patients with HCM and 37 normal subjects with similar age and gender distribution. Longitudinal LV strain (ε) and LA ε and strain rate (Sr) parameters (systolic, early diastolic, and late diastolic during atrial contraction) were assessed. Results: Peak LAε and LA Sr parameters were significantly lower in patients compared with controls (P ≤ .001 for all). In patients, all LA function parameters correlated with LVε (P < .003 for all). Indexed LA volume, LA function parameters, and mitral regurgitation degree were the main correlates of New York Heart Association class; late diastolic strain rate during atrial contraction was the only independent predictor of symptomatic status. Conclusion: In patients with HCM, LA function is significantly reduced and related to LV dysfunction. Moreover, LA booster pump function emerged as an independent correlate of heart failure symptoms in this setting.

Rosca, M., Popescu, B., Beladan, C., Calin, A., Muraru, D., Popa, E., et al. (2010). Left atrial dysfunction as a correlate of heart failure symptoms in hypertrophic cardiomyopathy. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 23(10), 1090-1098 [10.1016/j.echo.2010.07.016].

Left atrial dysfunction as a correlate of heart failure symptoms in hypertrophic cardiomyopathy

MURARU D;
2010

Abstract

Background: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. We aimed to assess left atrial (LA) function by two-dimensional speckle tracking echocardiography and its relation with left ventricular (LV) function and clinical status in patients with HCM. Methods: We prospectively enrolled 37 consecutive patients with HCM and 37 normal subjects with similar age and gender distribution. Longitudinal LV strain (ε) and LA ε and strain rate (Sr) parameters (systolic, early diastolic, and late diastolic during atrial contraction) were assessed. Results: Peak LAε and LA Sr parameters were significantly lower in patients compared with controls (P ≤ .001 for all). In patients, all LA function parameters correlated with LVε (P < .003 for all). Indexed LA volume, LA function parameters, and mitral regurgitation degree were the main correlates of New York Heart Association class; late diastolic strain rate during atrial contraction was the only independent predictor of symptomatic status. Conclusion: In patients with HCM, LA function is significantly reduced and related to LV dysfunction. Moreover, LA booster pump function emerged as an independent correlate of heart failure symptoms in this setting.
Articolo in rivista - Articolo scientifico
Deformation imaging; Hypertrophic cardiomyopathy; Left atrium; Left ventricle; Speckle tracking echocardiography;
English
2010
23
10
1090
1098
none
Rosca, M., Popescu, B., Beladan, C., Calin, A., Muraru, D., Popa, E., et al. (2010). Left atrial dysfunction as a correlate of heart failure symptoms in hypertrophic cardiomyopathy. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 23(10), 1090-1098 [10.1016/j.echo.2010.07.016].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/294663
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