Background-Right ventricular (RV) volumes and ejection fraction (EF) vary significantly with demographic and anthropometric factors and are associated with poor prognosis in several cardiovascular diseases. This multicenter study was designed to (1) establish the reference values for RV volumes and EF using transthoracic three-dimensional (3D) echocardiography; (2) investigate the influence of age, sex, and body size on RV anatomy; (3) develop normative equations. Methods and Results-RV volumes (end-diastolic volume and end-systolic volume), stroke volume, and EF were measured by 3D echocardiography in 540 healthy adult volunteers, prospectively enrolled, evenly distributed across age and sex. The relation of age, sex, and body size parameters was investigated using bivariate and multiple linear regression. Analysis was feasible in 507 (94%) subjects (260 women; age, 45±16 years; range, 18-90). Age, sex, height, and weight significantly influenced RV volumes and EF. Sex effect was significant (P<0.01), with RV volumes larger and EF smaller in men than in women. Older age was associated with lower volumes (end-diastolic volume, -5 mLdecade; end-systolic volume, -3 mL/decade; EF, -2 mL/decade) and higher EF (+1% per decade). Inclusion of body size parameters in the statistical models resulted in improved overall explained variance for volumes (end-diastolic volume, R2=0.43; end-systolic volume, R2=0.35; stroke volume, R2=0.30), while EF was unaffected. Ratiometric and allometric indexing for age, sex, and body size resulted in no significant residual correlation between RV measures and height or weight. Conclusions-The presented normative ranges and equations could help standardize the 3D echocardiography assessment of RV volumes and function in clinical practice, considering the effects of age, sex, and body size.

Maffessanti, F., Muraru, D., Esposito, R., Gripari, P., Ermacora, D., Santoro, C., et al. (2013). Age-, body size-, and sex-specific reference values for right ventricular volumes and ejection fraction by three-dimensional echocardiography: A multicenter echocardiographic study in 507 healthy volunteers. CIRCULATION. CARDIOVASCULAR IMAGING, 6(5), 700-710 [10.1161/CIRCIMAGING.113.000706].

Age-, body size-, and sex-specific reference values for right ventricular volumes and ejection fraction by three-dimensional echocardiography: A multicenter echocardiographic study in 507 healthy volunteers

MURARU, DENISA
Co-primo
;
BADANO, LUIGI
Ultimo
2013

Abstract

Background-Right ventricular (RV) volumes and ejection fraction (EF) vary significantly with demographic and anthropometric factors and are associated with poor prognosis in several cardiovascular diseases. This multicenter study was designed to (1) establish the reference values for RV volumes and EF using transthoracic three-dimensional (3D) echocardiography; (2) investigate the influence of age, sex, and body size on RV anatomy; (3) develop normative equations. Methods and Results-RV volumes (end-diastolic volume and end-systolic volume), stroke volume, and EF were measured by 3D echocardiography in 540 healthy adult volunteers, prospectively enrolled, evenly distributed across age and sex. The relation of age, sex, and body size parameters was investigated using bivariate and multiple linear regression. Analysis was feasible in 507 (94%) subjects (260 women; age, 45±16 years; range, 18-90). Age, sex, height, and weight significantly influenced RV volumes and EF. Sex effect was significant (P<0.01), with RV volumes larger and EF smaller in men than in women. Older age was associated with lower volumes (end-diastolic volume, -5 mLdecade; end-systolic volume, -3 mL/decade; EF, -2 mL/decade) and higher EF (+1% per decade). Inclusion of body size parameters in the statistical models resulted in improved overall explained variance for volumes (end-diastolic volume, R2=0.43; end-systolic volume, R2=0.35; stroke volume, R2=0.30), while EF was unaffected. Ratiometric and allometric indexing for age, sex, and body size resulted in no significant residual correlation between RV measures and height or weight. Conclusions-The presented normative ranges and equations could help standardize the 3D echocardiography assessment of RV volumes and function in clinical practice, considering the effects of age, sex, and body size.
Articolo in rivista - Articolo scientifico
Allometric equations; Echocardiography; Reference values; Right ventricular ejection fraction; Right ventricular volumes; Three-dimensional; Adolescent; Adult; Age Factors; Aged; Aged; 80 and over; Echocardiography; Three-Dimensional; Feasibility Studies; Female; Heart Ventricles; Humans; Italy; Linear Models; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prospective Studies; Reference Values; Sex Factors; Young Adult; Body Size; Stroke Volume; Ventricular Function; Right; Cardiology and Cardiovascular Medicine; Radiology; Nuclear Medicine and Imaging
English
27-giu-2013
2013
6
5
700
710
none
Maffessanti, F., Muraru, D., Esposito, R., Gripari, P., Ermacora, D., Santoro, C., et al. (2013). Age-, body size-, and sex-specific reference values for right ventricular volumes and ejection fraction by three-dimensional echocardiography: A multicenter echocardiographic study in 507 healthy volunteers. CIRCULATION. CARDIOVASCULAR IMAGING, 6(5), 700-710 [10.1161/CIRCIMAGING.113.000706].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/294537
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