Pyranoid spirofused sugar derivatives represent a class of compounds with a significant impact in the literature. Under the structural point of view, the rigidity inferred by the spirofused entity has made these compound object of interest mainly as enzymatic inhibitors, in particular of carbohydrate processing enzymes among which glycogen phosphorylase and sodium glucose co-transporter 2, important target enzymes for diverse pathological states. Most of the developed compounds present the spirofused entity at the C1 position of the sugar moiety, nevertheless spirofused entities can also be found at other sugar ring positions. The main spirofused entities encountered are spiroacetals/thioacetals, spiro-hydantoin and derivatives, spiro-isoxazolines, spiro-aminals, spiro-lactams, spiro-oxathiazole and spiro-oxazinanone, but also other are present.

La Ferla, B., & D'Orazio, G. (2021). Pyranoid Spirosugars as Enzyme Inhibitors. CURRENT ORGANIC SYNTHESIS, 18(1), 3-22 [10.2174/1570179417666200924152648].

Pyranoid Spirosugars as Enzyme Inhibitors

La Ferla, Barbara
;
D'Orazio, Giuseppe
2021

Abstract

Pyranoid spirofused sugar derivatives represent a class of compounds with a significant impact in the literature. Under the structural point of view, the rigidity inferred by the spirofused entity has made these compound object of interest mainly as enzymatic inhibitors, in particular of carbohydrate processing enzymes among which glycogen phosphorylase and sodium glucose co-transporter 2, important target enzymes for diverse pathological states. Most of the developed compounds present the spirofused entity at the C1 position of the sugar moiety, nevertheless spirofused entities can also be found at other sugar ring positions. The main spirofused entities encountered are spiroacetals/thioacetals, spiro-hydantoin and derivatives, spiro-isoxazolines, spiro-aminals, spiro-lactams, spiro-oxathiazole and spiro-oxazinanone, but also other are present.
No
Articolo in rivista - Review Essay
Scientifica
Glycomimetics; enzyme inhibitors; pyranoid structure; spiro-isoxazolines.; spirofused; sugar derivatives;
English
La Ferla, B., & D'Orazio, G. (2021). Pyranoid Spirosugars as Enzyme Inhibitors. CURRENT ORGANIC SYNTHESIS, 18(1), 3-22 [10.2174/1570179417666200924152648].
La Ferla, B; D'Orazio, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/292270
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