The loss of synapses and neurons in Alzheimer's disease (AD) is thought to be at least partly induced by toxic species formed by the amyloid beta (Aβ) peptide; therefore, therapeutics aimed at reducing Aβ toxicity could be of clinical use for treatment of AD. Liposomes are suitable vehicles for therapeutic agents and imaging probes, and a promising way of targeting the various Aβ forms. We tested liposomes functionalized with phosphatidic acid, cardiolipin, or GM1 ganglioside, previously shown to have high Aβ-binding capacity. Mimicking Aβ-induced toxicity in mouse neuroblastoma cell lines, combined with administration of cell viability-modulating agents, we observed that functionalized liposomes rescued cell viability to different extents. We also detected rescue of the imbalance of GSK-3β and PP2A activity, and reduction in tau phosphorylation. Thus, these liposomes appear particularly suitable for implementing further therapeutic strategies for AD.
Bereczki, E., Re, F., Masserini, M., Winblad, B., & Pei, J. (2011). Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells. NANOMEDICINE, 7(5), 560-571 [10.1016/j.nano.2011.05.009].
Citazione: | Bereczki, E., Re, F., Masserini, M., Winblad, B., & Pei, J. (2011). Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells. NANOMEDICINE, 7(5), 560-571 [10.1016/j.nano.2011.05.009]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | Si | |
Titolo: | Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells | |
Autori: | Bereczki, E; Re, F; Masserini, M; Winblad, B; Pei, J | |
Autori: | ||
Data di pubblicazione: | 2011 | |
Lingua: | English | |
Rivista: | NANOMEDICINE | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.nano.2011.05.009 | |
Appare nelle tipologie: | 01 - Articolo su rivista |