DNA is exposed to both endogenous and exogenous DNA damaging agents that chemically modify it. To counteract the deleterious effects exerted by DNA lesions, eukaryotic cells have evolved a network of cellular pathways, termed DNA damage response (DDR). The DDR comprises both mechanisms devoted to repair DNA lesions and signal transduction pathways that sense DNA damage and transduce this information to specific cellular targets. These targets, in turn, impact a wide range of cellular processes including DNA replication, DNA repair and cell cycle transitions. The importance of the DDR is highlighted by the fact that DDR inactivation is commonly found in cancer and causes many different human diseases. The protein kinases ATM and ATR, as well as their budding yeast orthologs Tel1 and Mec1, act as master regulators of the DDR. The initiating events in the DDR entail both DNA lesion recognition and assembly of protein complexes at the damaged DNA sites. Here, we review what is known about the early steps of the DDR.

Colombo, C., Gnugnoli, M., Gobbini, E., & Longhese, M. (2020). How do cells sense DNA lesions?. BIOCHEMICAL SOCIETY TRANSACTIONS, 48(2), 677-691 [10.1042/BST20191118].

How do cells sense DNA lesions?

Colombo, CV;Gnugnoli, M;Gobbini, E;Longhese, MP
2020

Abstract

DNA is exposed to both endogenous and exogenous DNA damaging agents that chemically modify it. To counteract the deleterious effects exerted by DNA lesions, eukaryotic cells have evolved a network of cellular pathways, termed DNA damage response (DDR). The DDR comprises both mechanisms devoted to repair DNA lesions and signal transduction pathways that sense DNA damage and transduce this information to specific cellular targets. These targets, in turn, impact a wide range of cellular processes including DNA replication, DNA repair and cell cycle transitions. The importance of the DDR is highlighted by the fact that DDR inactivation is commonly found in cancer and causes many different human diseases. The protein kinases ATM and ATR, as well as their budding yeast orthologs Tel1 and Mec1, act as master regulators of the DDR. The initiating events in the DDR entail both DNA lesion recognition and assembly of protein complexes at the damaged DNA sites. Here, we review what is known about the early steps of the DDR.
Articolo in rivista - Review Essay
Scientifica
ATM; ATR; DNA damage response; DNA recombination; DNA repair; single-stranded DNA
English
Colombo, C., Gnugnoli, M., Gobbini, E., & Longhese, M. (2020). How do cells sense DNA lesions?. BIOCHEMICAL SOCIETY TRANSACTIONS, 48(2), 677-691 [10.1042/BST20191118].
Colombo, C; Gnugnoli, M; Gobbini, E; Longhese, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/289008
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