Kaposi's sarcoma (KS) is a multifocal lesion that develops with high incidence in AIDS patients and is characterized by prominent angiogenesis. Both HHV8 and HIV are involved in the etiogenesis of epidemic KS, where imbalances between angiogenesis inducers and inhibitors appear to play a role. We have developed numerous primary cultures from Kaposi's sarcoma biopsies and studied factors involved in the induction and inhibition of KS associated angiogenesis. An immortal cell line developed in our laboratory, KS-Imm, gives rise to hemorrhagic tumors that resemble undifferentiated nodular KS when injected in nude mice. KS-CM supernatants, KS-Imm cells and purified HIV-Tat have been used to stimulate endothelial cells in vitro and angiogenesis in vivo in order to screen for anti-angiogenic compounds. We have tested several molecules for their capability to inhibit KS associated angiogenesis and tumor growth, such as class I interferons, retinoids, thrombospondin, somatostatin and N-acetyl-cysteine. Here we review the results obtained.
Morini, M., Marchisone, C., Pfeffer, U., Bisacchi, D., Carlone, S., Fassina, G., et al. (1999). Anti-angiogenic molecules as inhibitors of Kaposi's sarcoma. In F. Aiuti, F. Danese, I. Mezzaroma (a cura di), AIDS e Sindromi Correlate (pp. 195-201). Editore ed., International Proceeding Division.
Anti-angiogenic molecules as inhibitors of Kaposi's sarcoma
Albini A;
1999
Abstract
Kaposi's sarcoma (KS) is a multifocal lesion that develops with high incidence in AIDS patients and is characterized by prominent angiogenesis. Both HHV8 and HIV are involved in the etiogenesis of epidemic KS, where imbalances between angiogenesis inducers and inhibitors appear to play a role. We have developed numerous primary cultures from Kaposi's sarcoma biopsies and studied factors involved in the induction and inhibition of KS associated angiogenesis. An immortal cell line developed in our laboratory, KS-Imm, gives rise to hemorrhagic tumors that resemble undifferentiated nodular KS when injected in nude mice. KS-CM supernatants, KS-Imm cells and purified HIV-Tat have been used to stimulate endothelial cells in vitro and angiogenesis in vivo in order to screen for anti-angiogenic compounds. We have tested several molecules for their capability to inhibit KS associated angiogenesis and tumor growth, such as class I interferons, retinoids, thrombospondin, somatostatin and N-acetyl-cysteine. Here we review the results obtained.
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