Background: Little information is available on the long-term clinical outcome of cerebral vein thrombosis (CVT). Objectives and methods: In an international, retrospective cohort study, we assessed the long-term rates of mortality, residual disability and recurrent venous thromboembolism (VTE) in a cohort of patients with a first CVT episode. Results: Seven hundred and six patients (73.7% females) with CVT were included. Patients were followed for a total of 3171 patient-years. Median follow-up was 40months (range 6, 297months). At the end of follow-up, 20 patients had died (2.8%). The outcome was generally good: 89.1% of patients had a complete recovery (modified Rankin Score [mRS] 0-1) and 3.8% had a partial recovery and were independent (mRS 2). Eighty-four per cent of patients were treated with oral anticoagulants and the mean treatment duration was 12months. CVT recurred in 31 patients (4.4%), and 46 patients (6.5%) had a VTE in a different site, for an overall incidence of recurrence of 23.6 events per 1000 patient-years (95% confidence Interval [CI] 17.8, 28.7) and of 35.1 events/1000 patient-years (95% CI, 27.7, 44.4) after anticoagulant therapy withdrawal. A previous VTE was the only significant predictor of recurrence at multivariate analysis (hazard ratio [HR] 2.70; 95% CI 1.25, 5.83). Conclusions: The long-term risk of mortality and recurrent VTE appears to be low in patients who survived the acute phase of CVT. A previous VTE history independently predicts recurrent events.
Dentali, F., Poli, D., Scoditti, U., Di Minno, M., De Stefano, V., Stefano, V., et al. (2012). Long-term outcomes of patients with cerebral vein thrombosis: a multicenter study. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(7), 1297-1302 [10.1111/j.1538-7836.2012.04774.x].
|Citazione:||Dentali, F., Poli, D., Scoditti, U., Di Minno, M., De Stefano, V., Stefano, V., et al. (2012). Long-term outcomes of patients with cerebral vein thrombosis: a multicenter study. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(7), 1297-1302 [10.1111/j.1538-7836.2012.04774.x].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||Long-term outcomes of patients with cerebral vein thrombosis: a multicenter study|
|Autori:||Dentali, F; Poli, D; Scoditti, U; Di Minno, M; De Stefano, V; Stefano, V; Siragusa, S; Kostal, M; Palareti, G; Sartori, M; Grandone, E; Vedovati, M; Ageno, W; Falanga, A; Lerede, T; Bianchi, M; Testa, S; Witt, D; McCool, K; Bucherini, E; Grifoni, E; Coalizzo, D; Benedetti, R; Marietta, M; Sessa, M; Guaschino, C; di Minno, G; Tufano, A; Barbar, S; Malato, A; Pini, M; Castellini, P; Barco, S; Barone, M; Paciaroni, M; Alberti, A; Agnelli, G; Giorgi Pierfranceschi, M; Dulicek, P; Silingardi, M; Federica, L; Ghirarduzzi, A; Tiraferri, E; di Lazzaro, V; Rossi, E; Ciminello, A; Pasca, S; Barillari, G; Rezoagli, E; Galli, M; Squizzato, A; Tosetto, A|
|Data di pubblicazione:||2012|
|Rivista:||JOURNAL OF THROMBOSIS AND HAEMOSTASIS|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1538-7836.2012.04774.x|
|Appare nelle tipologie:||01 - Articolo su rivista|