The role of alcohol intake in the risk of Hodgkin lymphoma (HL) is still largely unclear. To summarize the evidence on the issue, we carried out a meta-analysis of the available studies. We identified eight case-control and two cohort studies, including a total of 1488 cases of HL. We derived meta-analytic estimates using random-effects models, taking into account the correlation between estimates, and carried out a dose-risk analysis using nonlinear random-effects metaregression models. Compared with nondrinkers, the relative risk for alcohol consumers was 0.70 [95% confidence interval (CI), 0.60-0.81] overall, 0.66 (95% CI, 0.56-0.78) among case-control, and 0.92 (95% CI, 0.63-1.33) among cohort studies. Compared with nondrinkers, the pooled relative risks were 0.71 (95% CI, 0.57-0.89) for light (i.e. <=1 drink/day) and 0.73 (95% CI, 0.60-0.87) for moderate-to-heavy (i.e. >1 drink/day) alcohol drinking. This meta-analysis suggests a favourable effect of alcohol on HL, in the absence, however, of a dose-risk relationship. The inverse association was restricted to - or greater in - case-control as compared with cohort studies. This indicates caution in the interpretation of results.

Tramacere, I., Pelucchi, C., Bonifazi, M., Bagnardi, V., Rota, M., Bellocco, R., et al. (2012). A meta-analysis on alcohol drinking and the risk of Hodgkin lymphoma. EUROPEAN JOURNAL OF CANCER PREVENTION, 21(3), 268-273 [10.1097/CEJ.0b013e328350b11b].

A meta-analysis on alcohol drinking and the risk of Hodgkin lymphoma

BAGNARDI, VINCENZO;ROTA, MATTEO;BELLOCCO, RINO;SCOTTI, LORENZA;CORRAO, GIOVANNI;
2012

Abstract

The role of alcohol intake in the risk of Hodgkin lymphoma (HL) is still largely unclear. To summarize the evidence on the issue, we carried out a meta-analysis of the available studies. We identified eight case-control and two cohort studies, including a total of 1488 cases of HL. We derived meta-analytic estimates using random-effects models, taking into account the correlation between estimates, and carried out a dose-risk analysis using nonlinear random-effects metaregression models. Compared with nondrinkers, the relative risk for alcohol consumers was 0.70 [95% confidence interval (CI), 0.60-0.81] overall, 0.66 (95% CI, 0.56-0.78) among case-control, and 0.92 (95% CI, 0.63-1.33) among cohort studies. Compared with nondrinkers, the pooled relative risks were 0.71 (95% CI, 0.57-0.89) for light (i.e. <=1 drink/day) and 0.73 (95% CI, 0.60-0.87) for moderate-to-heavy (i.e. >1 drink/day) alcohol drinking. This meta-analysis suggests a favourable effect of alcohol on HL, in the absence, however, of a dose-risk relationship. The inverse association was restricted to - or greater in - case-control as compared with cohort studies. This indicates caution in the interpretation of results.
Articolo in rivista - Articolo scientifico
alcohol drinking; dose–risk relation; Hodgkin lymphoma; meta-analysis; systematic review
English
268
273
6
Tramacere, I., Pelucchi, C., Bonifazi, M., Bagnardi, V., Rota, M., Bellocco, R., et al. (2012). A meta-analysis on alcohol drinking and the risk of Hodgkin lymphoma. EUROPEAN JOURNAL OF CANCER PREVENTION, 21(3), 268-273 [10.1097/CEJ.0b013e328350b11b].
Tramacere, I; Pelucchi, C; Bonifazi, M; Bagnardi, V; Rota, M; Bellocco, R; Scotti, L; Islami, F; Corrao, G; Boffetta, P; La Vecchia, C; Negri, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/28614
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