For the diagnosis of anti-MAG polyneuropathy the commercial ELISA manufacturer currently recommends a cut-off of 1000 Bühlmann Titer Units (BTU). We analyzed sera from 80 anti-MAG neuropathy patients and 383 controls (with other neuropathies or healthy controls) to assess the ELISA sensitivity and specificity at different thresholds. A better combination of sensitivity/specificity was found at a threshold >1500 BTU than at >1000 BTU. The best value of specificity was obtained at threshold >7000 BTU. There was a diagnostic grey area between 1500 and 7000 BTU in which the clinical phenotypes as well as electrophysiological studies need to be carefully assessed particularly to differentiate CIDP and anti-MAG neuropathy.

Liberatore, G., Giannotta, C., Sajeev, B., Morenghi, E., Terenghi, F., Gallia, F., et al. (2020). Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy. JOURNAL OF NEUROIMMUNOLOGY, 345 [10.1016/j.jneuroim.2020.577288].

Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy

Cavaletti G.;
2020

Abstract

For the diagnosis of anti-MAG polyneuropathy the commercial ELISA manufacturer currently recommends a cut-off of 1000 Bühlmann Titer Units (BTU). We analyzed sera from 80 anti-MAG neuropathy patients and 383 controls (with other neuropathies or healthy controls) to assess the ELISA sensitivity and specificity at different thresholds. A better combination of sensitivity/specificity was found at a threshold >1500 BTU than at >1000 BTU. The best value of specificity was obtained at threshold >7000 BTU. There was a diagnostic grey area between 1500 and 7000 BTU in which the clinical phenotypes as well as electrophysiological studies need to be carefully assessed particularly to differentiate CIDP and anti-MAG neuropathy.
Articolo in rivista - Articolo scientifico
Anti-MAG polyneuropathy, chronic inflammatory demyelinating polyradiculoneuropathy; ELISA; Sensitivity; Specificity
English
2020
345
577288
none
Liberatore, G., Giannotta, C., Sajeev, B., Morenghi, E., Terenghi, F., Gallia, F., et al. (2020). Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy. JOURNAL OF NEUROIMMUNOLOGY, 345 [10.1016/j.jneuroim.2020.577288].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/285282
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