Aim: We investigated the use of cellulose nanocrystals (CNCs) as drug nanocarriers combining an anti-osteoporotic agent, alendronate (ALN), and an anti-cancer drug, doxorubicin (DOX). Materials & methods: CNC physicochemical characterization, in vivo imaging coupled with histology and in vitro uptake and toxicity assays were carried out. Results: In vivo CNC-ALN did not modify bone tropism and lung penetration, whereas its liver and kidney accumulation was slightly higher compared with CNCs alone. In vitro studies showed that CNC-ALN did not impair ALN's effect on osteoclasts, whereas CNC-DOX confirmed the therapeutic potential against bone metastatic cancer cells. Conclusions: This study provides robust proof of the potential of CNCs as easy, flexible and specific carriers to deliver compounds to the bone.

Zoia, L., Morelli, A., Talamini, L., Violatto, M., Lovati, A., Lopa, S., et al. (2020). Cellulose nanocrystals: A multimodal tool to enhance the targeted drug delivery against bone disorders. NANOMEDICINE, 15(23), 2271-2285 [10.2217/nnm-2020-0139].

Cellulose nanocrystals: A multimodal tool to enhance the targeted drug delivery against bone disorders

Zoia, Luca;Morelli, Annalisa;Salanti, Anika;Ferla, Barbara La;
2020

Abstract

Aim: We investigated the use of cellulose nanocrystals (CNCs) as drug nanocarriers combining an anti-osteoporotic agent, alendronate (ALN), and an anti-cancer drug, doxorubicin (DOX). Materials & methods: CNC physicochemical characterization, in vivo imaging coupled with histology and in vitro uptake and toxicity assays were carried out. Results: In vivo CNC-ALN did not modify bone tropism and lung penetration, whereas its liver and kidney accumulation was slightly higher compared with CNCs alone. In vitro studies showed that CNC-ALN did not impair ALN's effect on osteoclasts, whereas CNC-DOX confirmed the therapeutic potential against bone metastatic cancer cells. Conclusions: This study provides robust proof of the potential of CNCs as easy, flexible and specific carriers to deliver compounds to the bone.
Articolo in rivista - Articolo scientifico
bone tropism; cellulose nanocrystals; drug-delivery system; surface functionalization;
bone tropism; cellulose nanocrystals; drug-delivery system; surface functionalization
English
2020
15
23
2271
2285
none
Zoia, L., Morelli, A., Talamini, L., Violatto, M., Lovati, A., Lopa, S., et al. (2020). Cellulose nanocrystals: A multimodal tool to enhance the targeted drug delivery against bone disorders. NANOMEDICINE, 15(23), 2271-2285 [10.2217/nnm-2020-0139].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/285098
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