We have previously shown that the sustained expression of MARK4L transcripts in glioma and neural progenitors (NHNPs) declines after exposure to antisense MARK4L oligonucleotides in glioblastoma cell lines. Array-CGH confirmed the genomic duplication of MARK4L identified by FISH in a glioblastoma cell line. This background together with literature data on the exogenous association of MARK4 with interphase centrosome prompted us to investigate the sub-cellular localization of the endogenous MARK4L protein aiming at achieving insights on its possible role in the pathomechanisms of glioma.

Magnani, I., Novielli, C., Bellini, M., Roversi, G., Bello, L., Larizza, L. (2009). Multiple localization of endogenous MARK4L protein in human glioma. CELLULAR ONCOLOGY, 31(5), 357-370 [10.3233/CLO-2009-0481].

Multiple localization of endogenous MARK4L protein in human glioma

ROVERSI, GAIA;
2009

Abstract

We have previously shown that the sustained expression of MARK4L transcripts in glioma and neural progenitors (NHNPs) declines after exposure to antisense MARK4L oligonucleotides in glioblastoma cell lines. Array-CGH confirmed the genomic duplication of MARK4L identified by FISH in a glioblastoma cell line. This background together with literature data on the exogenous association of MARK4 with interphase centrosome prompted us to investigate the sub-cellular localization of the endogenous MARK4L protein aiming at achieving insights on its possible role in the pathomechanisms of glioma.
Articolo in rivista - Articolo scientifico
Cell Nucleus; Immunoprecipitation; Protein-Serine-Threonine Kinases; Interphase; Molecular Weight; Antibodies; Glioma; Humans; Stem Cells; Cell Line, Tumor; Mitosis; Neurons; Mass Spectrometry; Centrosome; Subcellular Fractions
English
357
370
Magnani, I., Novielli, C., Bellini, M., Roversi, G., Bello, L., Larizza, L. (2009). Multiple localization of endogenous MARK4L protein in human glioma. CELLULAR ONCOLOGY, 31(5), 357-370 [10.3233/CLO-2009-0481].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/28441
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