In this paper, the plasma glucose regulation problem for Type 2 diabetic patients is studied. A nonlinear time-delay model of the glucose-insulin regulatory system is exploited in order to design a sampled-data static output feedback control, which makes use of only sampled glucose measurements. It is shown that the proposed control law is a stabilizer in the sampled-and-hold sense. The presence of a state-delay in the model prevents the availability in the buffer of suitable needed past values of the glucose. Such a drawback is overcome by means of spline interpolation. A pre-clinical validation, concerning the performances of the proposed glucose control law, is carried out by means of a well known simulator of diabetic patients broadly accepted for testing insulin infusion therapies. Simulations results are encouraging for further evaluation.

Di Ferdinando, M., Pepe, P., Di Gennaro, S., Palumbo, P. (2020). Sampled-Data Static Output Feedback Control of the Glucose-Insulin System. In 21st IFAC World Congress 2020 (pp.3626-3631). Elsevier B.V. [10.1016/j.ifacol.2020.12.2044].

Sampled-Data Static Output Feedback Control of the Glucose-Insulin System

Palumbo, P
2020

Abstract

In this paper, the plasma glucose regulation problem for Type 2 diabetic patients is studied. A nonlinear time-delay model of the glucose-insulin regulatory system is exploited in order to design a sampled-data static output feedback control, which makes use of only sampled glucose measurements. It is shown that the proposed control law is a stabilizer in the sampled-and-hold sense. The presence of a state-delay in the model prevents the availability in the buffer of suitable needed past values of the glucose. Such a drawback is overcome by means of spline interpolation. A pre-clinical validation, concerning the performances of the proposed glucose control law, is carried out by means of a well known simulator of diabetic patients broadly accepted for testing insulin infusion therapies. Simulations results are encouraging for further evaluation.
paper
Sampled-Data Static Output Feedback Controllers, Nonlinear Time-Delay Systems, Stabilization in the Sample-and-Hold sense, Glucose-Insulin model, In silico validation;
English
21st IFAC World Congress 2020 - 12 July 2020 through 17 July 2020
2020
Findeisen, R; Hirche, S; Janschek, K; Mönnigmann, M
21st IFAC World Congress 2020
2020
53
2
3626
3631
open
Di Ferdinando, M., Pepe, P., Di Gennaro, S., Palumbo, P. (2020). Sampled-Data Static Output Feedback Control of the Glucose-Insulin System. In 21st IFAC World Congress 2020 (pp.3626-3631). Elsevier B.V. [10.1016/j.ifacol.2020.12.2044].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/284075
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