Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alterations, which represents a marker of poor prognosis, was strictly correlated with an immature DH/JH rearrangement of the immunoglobulin receptor (p < 0.0001). Furthermore, TP53-mutated patients were classified as pro-B ALL more frequently than their wild-type counterpart (46% vs. 25%, p = 0.05). Although the reasons for the co-presence of immature Ig rearrangements and TP53 mutation need to be clarified, this can suggest that the alteration in TP53 is acquired at an early stage of B-cell maturation or even at the level of pre-leukemic transformation.

Salmoiraghi, S., Cavagna, R., Montalvo, M., Ubiali, G., Tosi, M., Peruta, B., et al. (2020). Immature immunoglobulin gene rearrangements are recurrent in B precursor adult acute lymphoblastic leukemia carrying TP53 molecular alterations. GENES, 11(9), 1-6 [10.3390/genes11090960].

Immature immunoglobulin gene rearrangements are recurrent in B precursor adult acute lymphoblastic leukemia carrying TP53 molecular alterations

Salmoiraghi S.
;
Intermesoli T.
;
2020

Abstract

Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alterations, which represents a marker of poor prognosis, was strictly correlated with an immature DH/JH rearrangement of the immunoglobulin receptor (p < 0.0001). Furthermore, TP53-mutated patients were classified as pro-B ALL more frequently than their wild-type counterpart (46% vs. 25%, p = 0.05). Although the reasons for the co-presence of immature Ig rearrangements and TP53 mutation need to be clarified, this can suggest that the alteration in TP53 is acquired at an early stage of B-cell maturation or even at the level of pre-leukemic transformation.
No
Articolo in rivista - Articolo scientifico
Scientifica
Acute lymphoblastic leukemia; Immunoglobulin rearrangements; TP53
English
1
6
6
Salmoiraghi, S., Cavagna, R., Montalvo, M., Ubiali, G., Tosi, M., Peruta, B., et al. (2020). Immature immunoglobulin gene rearrangements are recurrent in B precursor adult acute lymphoblastic leukemia carrying TP53 molecular alterations. GENES, 11(9), 1-6 [10.3390/genes11090960].
Salmoiraghi, S; Cavagna, R; Montalvo, M; Ubiali, G; Tosi, M; Peruta, B; Intermesoli, T; Oldani, E; Salvi, A; Pavoni, C; Giussani, U; Bassan, R; Rambaldi, A; Spinelli, O
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/283297
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