Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alterations, which represents a marker of poor prognosis, was strictly correlated with an immature DH/JH rearrangement of the immunoglobulin receptor (p < 0.0001). Furthermore, TP53-mutated patients were classified as pro-B ALL more frequently than their wild-type counterpart (46% vs. 25%, p = 0.05). Although the reasons for the co-presence of immature Ig rearrangements and TP53 mutation need to be clarified, this can suggest that the alteration in TP53 is acquired at an early stage of B-cell maturation or even at the level of pre-leukemic transformation.
Salmoiraghi, S., Cavagna, R., Montalvo, M., Ubiali, G., Tosi, M., Peruta, B., et al. (2020). Immature immunoglobulin gene rearrangements are recurrent in B precursor adult acute lymphoblastic leukemia carrying TP53 molecular alterations. GENES, 11(9), 1-6 [10.3390/genes11090960].
Citazione: | Salmoiraghi, S., Cavagna, R., Montalvo, M., Ubiali, G., Tosi, M., Peruta, B., et al. (2020). Immature immunoglobulin gene rearrangements are recurrent in B precursor adult acute lymphoblastic leukemia carrying TP53 molecular alterations. GENES, 11(9), 1-6 [10.3390/genes11090960]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Immature immunoglobulin gene rearrangements are recurrent in B precursor adult acute lymphoblastic leukemia carrying TP53 molecular alterations | |
Autori: | Salmoiraghi, S; Cavagna, R; Montalvo, M; Ubiali, G; Tosi, M; Peruta, B; Intermesoli, T; Oldani, E; Salvi, A; Pavoni, C; Giussani, U; Bassan, R; Rambaldi, A; Spinelli, O | |
Autori: | ||
Data di pubblicazione: | 2020 | |
Lingua: | English | |
Rivista: | GENES | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/genes11090960 | |
Appare nelle tipologie: | 01 - Articolo su rivista |