Background: Hydroxychloroquine (HCQ) was proposed as potential treatment for COVID-19. Objective: We set-up a multicenter Italian collaboration to investigate the relationship between HCQ therapy and COVID-19 in-hospital mortality. Methods: In a retrospective observational study, 3,451 unselected patients hospitalized in 33 clinical centers in Italy, from February 19, 2020 to May 23, 2020, with laboratory-confirmed SARS-CoV-2 infection, were analyzed. The primary end-point in a time-to event analysis was in-hospital death, comparing patients who received HCQ with patients who did not. We used multivariable Cox proportional-hazards regression models with inverse probability for treatment weighting by propensity scores, with the addition of subgroup analyses. Results: Out of 3,451 COVID-19 patients, 76.3% received HCQ. Death rates (per 1,000 person-days) for patients receiving or not HCQ were 8.9 and 15.7, respectively. After adjustment for propensity scores, we found 30% lower risk of death in patients receiving HCQ (HR=0.70; 95%CI: 0.59 to 0.84; E-value=1.67). Secondary analyses yielded similar results. The inverse association of HCQ with inpatient mortality was particularly evident in patients having elevated C-reactive protein at entry. Conclusions: HCQ use was associated with a 30% lower risk of death in COVID-19 hospitalized patients. Within the limits of an observational study and awaiting results from randomized controlled trials, these data do not discourage the use of HCQ in inpatients with COVID-19.
Castelnuovo, A., Costanzo, S., Antinori, A., Berselli, N., Blandi, L., Bruno, R., et al. (2020). Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 82, 38-47.
|Citazione:||Castelnuovo, A., Costanzo, S., Antinori, A., Berselli, N., Blandi, L., Bruno, R., et al. (2020). Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 82, 38-47.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study|
|Autori:||Castelnuovo, A; Costanzo, S; Antinori, A; Berselli, N; Blandi, L; Bruno, R; Cauda, R; Guaraldi, G; Menicanti, L; My, I; Parruti, G; Patti, G; Perlini, S; Santilli, F; Signorelli, C; Spinoni, E; Stefanini, G; Vergori, A; Ageno, W; Agodi, A; Aiello, L; Agostoni, P; Moghazi, S; Astuto, M; Aucella, F; Barbieri, G; Bartoloni, A; Bonaccio, M; Bonfanti, P; Cacciatore, F; Caiano, L; Cannata, F; Carrozzi, L; Cascio, A; Ciccullo, A; Cingolani, A; Cipollone, F; Colomba, C; Crosta, F; Pra, C; Danzi, G; D'Ardes, D; Donati, K; Giacomo, P; Gennaro, F; Tano, G; D'Offizi, G; Filippini, T; Fusco, F; Gentile, I; Gialluisi, A; Gini, G; Grandone, E; Grisafi, L; Guarnieri, G; Lamonica, S; Landi, F; Leone, A; Maccagni, G; Maccarella, S; Madaro, A; Mapelli, M; Maragna, R; Marra, L; Maresca, G; Marotta, C; Mastroianni, F; Mazzitelli, M; Mengozzi, A; Menichetti, F; Meschiari, M; Minutolo, F; Montineri, A; Mussinelli, R; Mussini, C; Musso, M; Odone, A; Olivieri, M; Pasi, E; Petri, F; Pinchera, B; Pivato, C; Poletti, V; Ravaglia, C; Rinaldi, M; Rognoni, A; Rossato, M; Rossi, I; Rossi, M; Sabena, A; Salinaro, F; Sangiovanni, V; Sanrocco, C; Scorzolini, L; Sgariglia, R; Simeone, P; Spinicci, M; Trecarichi, E; Venezia, A; Veronesi, G; Vettor, R; Vianello, A; Vinceti, M; Vocciante, L; De Caterina, R; Iacoviello, L|
|Data di pubblicazione:||2020|
|Rivista:||EUROPEAN JOURNAL OF INTERNAL MEDICINE|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ejim.2020.08.019|
|Appare nelle tipologie:||01 - Articolo su rivista|