Objective: To provide a state of the art of economic analyses applied to rheumatoid arthritis (RA). Methods: A systematic literature review on economic consequences and pharmacoeconomic issues of RA was performed. Results: 127 valid articles were examined in this review. Generally, the financial impact of RA is substantial for health-care systems and society worldwide, although differences exist among national economies. Both direct and indirect (i.e. loss of productivity) costs contribute to economic burden of RA and must be taken into account when estimating overall impact to society. Disease severity, disease activity, age and socioeconomic status have been found to be the most relevant predictors of cost increase in RA. Moreover, introduction of biological anti-rheumatic agents has significantly raised direct medical costs in certain patients, but has also led to marked improvements in reducing disease activity, joint damage, and productivity loss in many of these patients. RA has also a significant impact on all aspects of quality of life; recent publications on health utility scores showed RA to be one of the diseases associated with poorest quality of life. Conclusions: RA represents a clinical and economic burden for healthcare systems. Although attributable RA costs have been extensively evaluated over the last decades, several issues, especially concerning the use of expensive therapies, must be addressed and frequently updated. Future research should also provide health economic evidence from usual practice settings, and on the economic impact of different therapeutic approaches to pursue specific clinical targets in individual patients. © Copyright Clinical and Experimental Rheumatology 2012.

Furneri, G., Mantovani, L., Belisari, A., Cristiani, M., Bellelli, S., Cortesi, P., et al. (2012). Systematic literature review on economic implications and pharmacoeconomic issues of rheumatoid arthritis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 30(4 suppl 73), 72-84.

Systematic literature review on economic implications and pharmacoeconomic issues of rheumatoid arthritis

Mantovani LG
Secondo
;
Cortesi PA
Penultimo
;
2012

Abstract

Objective: To provide a state of the art of economic analyses applied to rheumatoid arthritis (RA). Methods: A systematic literature review on economic consequences and pharmacoeconomic issues of RA was performed. Results: 127 valid articles were examined in this review. Generally, the financial impact of RA is substantial for health-care systems and society worldwide, although differences exist among national economies. Both direct and indirect (i.e. loss of productivity) costs contribute to economic burden of RA and must be taken into account when estimating overall impact to society. Disease severity, disease activity, age and socioeconomic status have been found to be the most relevant predictors of cost increase in RA. Moreover, introduction of biological anti-rheumatic agents has significantly raised direct medical costs in certain patients, but has also led to marked improvements in reducing disease activity, joint damage, and productivity loss in many of these patients. RA has also a significant impact on all aspects of quality of life; recent publications on health utility scores showed RA to be one of the diseases associated with poorest quality of life. Conclusions: RA represents a clinical and economic burden for healthcare systems. Although attributable RA costs have been extensively evaluated over the last decades, several issues, especially concerning the use of expensive therapies, must be addressed and frequently updated. Future research should also provide health economic evidence from usual practice settings, and on the economic impact of different therapeutic approaches to pursue specific clinical targets in individual patients. © Copyright Clinical and Experimental Rheumatology 2012.
Articolo in rivista - Articolo scientifico
Cost Fecctiveness
English
2012
30
4 suppl 73
72
84
none
Furneri, G., Mantovani, L., Belisari, A., Cristiani, M., Bellelli, S., Cortesi, P., et al. (2012). Systematic literature review on economic implications and pharmacoeconomic issues of rheumatoid arthritis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 30(4 suppl 73), 72-84.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/282143
Citazioni
  • Scopus 87
  • ???jsp.display-item.citation.isi??? 79
Social impact