IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishBackground: To assess the association between admission serum uric acid (SUA) levels and in-hospital outcomes in a real-world patients population with acute coronary syndrome (ACS) and to investigate the potential incremental prognostic value of SUA added to GRACE score (GRACE-SUA score). Methods: The data of consecutive ACS patients admitted to Coronary Care Unit of San Paolo and Niguarda hospitals in Milan (Italy) were retrospectively analyzed. Results: 1088 patients (24% female) were enrolled. Mean age was 68 years (IQR 60–78). STEMI and NSTE-ACS patients were 504 (46%) and 584 (54%) respectively. SUA (OR 1.72 95%CI 1.33–2.22, p < 0.0001) and GRACE score (OR 1.04 95%CI 1.02–1.06, p < 0.0001) were significantly associated with an increased risk of in-hospital death at the multivariate analysis. Admission values of SUA were stratified in four quartiles. Rates of acute kidney injury, implantation of intra-aortic balloon pump and non-invasive ventilation use were significantly higher in the last quartile compared to Q1, Q2 and Q3 (p < 0.01). The areas under the ROC curve (AUC) for GRACE score and for SUA were 0.91 (95% CI 0.89–0.93, p < 0.0001) and 0.79 (95% CI 0.76–0.81, p < 0.0001) respectively. The AUC was larger for predicting in-hospital mortality with the GRACE-SUA score (0.94; 95% CI 0.93–0.95). Conclusions: High admission levels of SUA are independently associated with in-hospital adverse outcomes and mortality in a contemporary population of ACS patients. The inclusion of SUA to GRACE risk score seems to lead to a more accurate prediction of in-hospital mortality in this study population.
Centola, M., Maloberti, A., Castini, D., Persampieri, S., Sabatelli, L., Ferrante, G., et al. (2020). Impact of admission serum acid uric levels on in-hospital outcomes in patients with acute coronary syndrome. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 82, 62-67 [10.1016/j.ejim.2020.07.013].
| Citazione: | Centola, M., Maloberti, A., Castini, D., Persampieri, S., Sabatelli, L., Ferrante, G., et al. (2020). Impact of admission serum acid uric levels on in-hospital outcomes in patients with acute coronary syndrome. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 82, 62-67 [10.1016/j.ejim.2020.07.013]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | Impact of admission serum acid uric levels on in-hospital outcomes in patients with acute coronary syndrome | |
| Autori: | Centola, M; Maloberti, A; Castini, D; Persampieri, S; Sabatelli, L; Ferrante, G; Lucreziotti, S; Morici, N; Sacco, A; Oliva, F; Rebora, P; Giannattasio, C; Mafrici, A; Carugo, S | |
| Autori: | ||
| Data di pubblicazione: | 2020 | |
| Lingua: | English | |
| Rivista: | EUROPEAN JOURNAL OF INTERNAL MEDICINE | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.ejim.2020.07.013 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
Copyright © 2022