Background: To assess the association between admission serum uric acid (SUA) levels and in-hospital outcomes in a real-world patients population with acute coronary syndrome (ACS) and to investigate the potential incremental prognostic value of SUA added to GRACE score (GRACE-SUA score). Methods: The data of consecutive ACS patients admitted to Coronary Care Unit of San Paolo and Niguarda hospitals in Milan (Italy) were retrospectively analyzed. Results: 1088 patients (24% female) were enrolled. Mean age was 68 years (IQR 60–78). STEMI and NSTE-ACS patients were 504 (46%) and 584 (54%) respectively. SUA (OR 1.72 95%CI 1.33–2.22, p < 0.0001) and GRACE score (OR 1.04 95%CI 1.02–1.06, p < 0.0001) were significantly associated with an increased risk of in-hospital death at the multivariate analysis. Admission values of SUA were stratified in four quartiles. Rates of acute kidney injury, implantation of intra-aortic balloon pump and non-invasive ventilation use were significantly higher in the last quartile compared to Q1, Q2 and Q3 (p < 0.01). The areas under the ROC curve (AUC) for GRACE score and for SUA were 0.91 (95% CI 0.89–0.93, p < 0.0001) and 0.79 (95% CI 0.76–0.81, p < 0.0001) respectively. The AUC was larger for predicting in-hospital mortality with the GRACE-SUA score (0.94; 95% CI 0.93–0.95). Conclusions: High admission levels of SUA are independently associated with in-hospital adverse outcomes and mortality in a contemporary population of ACS patients. The inclusion of SUA to GRACE risk score seems to lead to a more accurate prediction of in-hospital mortality in this study population.
Centola, M., Maloberti, A., Castini, D., Persampieri, S., Sabatelli, L., Ferrante, G., et al. (2020). Impact of admission serum acid uric levels on in-hospital outcomes in patients with acute coronary syndrome. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 82, 62-67 [10.1016/j.ejim.2020.07.013].
|Citazione:||Centola, M., Maloberti, A., Castini, D., Persampieri, S., Sabatelli, L., Ferrante, G., et al. (2020). Impact of admission serum acid uric levels on in-hospital outcomes in patients with acute coronary syndrome. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 82, 62-67 [10.1016/j.ejim.2020.07.013].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||Impact of admission serum acid uric levels on in-hospital outcomes in patients with acute coronary syndrome|
|Autori:||Centola, M; Maloberti, A; Castini, D; Persampieri, S; Sabatelli, L; Ferrante, G; Lucreziotti, S; Morici, N; Sacco, A; Oliva, F; Rebora, P; Giannattasio, C; Mafrici, A; Carugo, S|
CENTOLA, MARCO (Corresponding)
|Data di pubblicazione:||2020|
|Rivista:||EUROPEAN JOURNAL OF INTERNAL MEDICINE|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ejim.2020.07.013|
|Appare nelle tipologie:||01 - Articolo su rivista|