[11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol.

Coliva, A., Monterisi, C., Apollaro, A., Gatti, D., Penso, M., Gianolli, L., et al. (2015). Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis. APPLIED RADIATION AND ISOTOPES, 105, 66-71 [10.1016/j.apradiso.2015.07.003].

Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis

Coliva A.;Monterisi C.;Gilardi M. C.;
2015

Abstract

[11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol.
Articolo in rivista - Articolo scientifico
Alzheimer's disease, Cyclotron, [11C]MeOTf, [11C]PIB, β-amyloid
English
2015
105
66
71
none
Coliva, A., Monterisi, C., Apollaro, A., Gatti, D., Penso, M., Gianolli, L., et al. (2015). Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis. APPLIED RADIATION AND ISOTOPES, 105, 66-71 [10.1016/j.apradiso.2015.07.003].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/279801
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