Introduction The UPDRS-IV represents the most common screening tool to assess motor fluctuations in patients with PD despite the lack of a clinimetric validation. Objectives We evaluated sensitivity and specificity of UPDRS-IV using a 12-h waking-day motor assessment as the gold standard. Methods We consecutively enrolled PD patients who underwent a 12-h waking-day motor assessment in the study. Patients were clinically evaluated every 2 h for 12 h using the UPDRS-III. Motor scores were reported as a line graph and six blinded raters classified patients as having or not having motor fluctuations. The UPDRS-IV was used in order to assess the presence of predictable and unpredictable motor fluctuations according to items 36–38. Results Sixty two PD patients were enrolled in the study. According to the raters’ evaluations, 39 (62.9%) were classified as having motor fluctuations, while according to the UPDRS-IV 47 (75.8%) presented a motor fluctuation giving a sensitivity of 87.2% (95%CI 72.6–95.7) and a specificity of 43.5% (95%CI 23.2–65.5). Conclusion Our study results confirm the high level of sensitivity with a lower level of specificity of UPDRS-IV to screen motor fluctuations in PD patients.

Raciti, L., Nicoletti, A., Mostile, G., Bonomo, R., Contrafatto, D., Dibilio, V., et al. (2016). Validation of the UPDRS section IV for detection of motor fluctuations in Parkinson's disease. PARKINSONISM & RELATED DISORDERS, 27, 98-101 [10.1016/j.parkreldis.2016.03.008].

Validation of the UPDRS section IV for detection of motor fluctuations in Parkinson's disease

Bonomo R.;
2016

Abstract

Introduction The UPDRS-IV represents the most common screening tool to assess motor fluctuations in patients with PD despite the lack of a clinimetric validation. Objectives We evaluated sensitivity and specificity of UPDRS-IV using a 12-h waking-day motor assessment as the gold standard. Methods We consecutively enrolled PD patients who underwent a 12-h waking-day motor assessment in the study. Patients were clinically evaluated every 2 h for 12 h using the UPDRS-III. Motor scores were reported as a line graph and six blinded raters classified patients as having or not having motor fluctuations. The UPDRS-IV was used in order to assess the presence of predictable and unpredictable motor fluctuations according to items 36–38. Results Sixty two PD patients were enrolled in the study. According to the raters’ evaluations, 39 (62.9%) were classified as having motor fluctuations, while according to the UPDRS-IV 47 (75.8%) presented a motor fluctuation giving a sensitivity of 87.2% (95%CI 72.6–95.7) and a specificity of 43.5% (95%CI 23.2–65.5). Conclusion Our study results confirm the high level of sensitivity with a lower level of specificity of UPDRS-IV to screen motor fluctuations in PD patients.
Articolo in rivista - Articolo scientifico
Motor fluctuations; Sensitivity and specificity; UPDRS; Aged; Dopamine Agonists; Female; Humans; Levodopa; Male; Middle Aged; Motor Skills Disorders; Parkinson Disease; Single-Blind Method; Severity of Illness Index
English
2016
27
98
101
reserved
Raciti, L., Nicoletti, A., Mostile, G., Bonomo, R., Contrafatto, D., Dibilio, V., et al. (2016). Validation of the UPDRS section IV for detection of motor fluctuations in Parkinson's disease. PARKINSONISM & RELATED DISORDERS, 27, 98-101 [10.1016/j.parkreldis.2016.03.008].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/279213
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