Several novel non-antibiotic therapies have been used in patients with pneumonia. Among many alternatives, anti-inflammatory and immunomodulatory agents such as corticosteroids, statins, nonsteroid anti-inflammatory medications, immunoglobulins and anticoagulants have been tested. Other agents, such as angiotensin-converting enzyme inhibitors and mucolytics, showed a potential beneficial effect on airways protection mechanisms and secretion clearance. The therapeutic effect of nonpharmacological strategies (i.e. chest physiotherapy) has also been considered. However, other than use of corticosteroids in certain populations, there is still a need for further research before these medications are recommended forclinicaluse.This chapter discusses the evidence regarding novel non-antibiotic therapies and the association with clinical outcomes in patients with pneumonia. © 2014.
Faverio, P., Restrepo, M. (2014). Non-antibiotic therapies for CAP. In European Respiratory Monograph (pp. 219-233). European Respiratory Society [10.1183/1025448x.10004513].
Non-antibiotic therapies for CAP
Faverio, P;
2014
Abstract
Several novel non-antibiotic therapies have been used in patients with pneumonia. Among many alternatives, anti-inflammatory and immunomodulatory agents such as corticosteroids, statins, nonsteroid anti-inflammatory medications, immunoglobulins and anticoagulants have been tested. Other agents, such as angiotensin-converting enzyme inhibitors and mucolytics, showed a potential beneficial effect on airways protection mechanisms and secretion clearance. The therapeutic effect of nonpharmacological strategies (i.e. chest physiotherapy) has also been considered. However, other than use of corticosteroids in certain populations, there is still a need for further research before these medications are recommended forclinicaluse.This chapter discusses the evidence regarding novel non-antibiotic therapies and the association with clinical outcomes in patients with pneumonia. © 2014.
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