Background: Immunological causes of parkinsonism are very rare and usually characterized by early presentation, poor response to levodopa, and additional clinical features. Case presentation: We describe a 58-year-old white man who presented with a 1-year history of gait disturbance with disequilibrium leading to falls. We report an association between parkinsonism and presence of anti-glutamic acid decarboxylase antibodies in his cerebrospinal fluid, discussing clinical presentation and follow-up. Conclusions: Besides the possibility of a casual association, this case allows us to hypothesize an alternative pathophysiological mechanism of parkinsonism implying interference with glutamic acid decarboxylase and gamma-aminobutyric acid functions, eventually resulting in basal ganglia circuit dysregulation.

Stefanoni, G., Formenti, A., Tremolizzo, L., Stabile, A., Appollonio, I., Ferrarese, C. (2020). Atypical parkinsonism and intrathecal anti-glutamic acid decarboxylase antibodies - An unusual association: A case report. JOURNAL OF MEDICAL CASE REPORTS, 14(1) [10.1186/s13256-020-02412-x].

Atypical parkinsonism and intrathecal anti-glutamic acid decarboxylase antibodies - An unusual association: A case report

Stefanoni, Giovanni
;
Formenti, Anna;Tremolizzo, Lucio;Stabile, Andrea;Appollonio, Ildebrando;Ferrarese, Carlo
2020

Abstract

Background: Immunological causes of parkinsonism are very rare and usually characterized by early presentation, poor response to levodopa, and additional clinical features. Case presentation: We describe a 58-year-old white man who presented with a 1-year history of gait disturbance with disequilibrium leading to falls. We report an association between parkinsonism and presence of anti-glutamic acid decarboxylase antibodies in his cerebrospinal fluid, discussing clinical presentation and follow-up. Conclusions: Besides the possibility of a casual association, this case allows us to hypothesize an alternative pathophysiological mechanism of parkinsonism implying interference with glutamic acid decarboxylase and gamma-aminobutyric acid functions, eventually resulting in basal ganglia circuit dysregulation.
Articolo in rivista - Articolo scientifico
Anti-GAD antibodies; Atypical parkinsonism; Intrathecal antibodies;
English
30-giu-2020
2020
14
1
84
open
Stefanoni, G., Formenti, A., Tremolizzo, L., Stabile, A., Appollonio, I., Ferrarese, C. (2020). Atypical parkinsonism and intrathecal anti-glutamic acid decarboxylase antibodies - An unusual association: A case report. JOURNAL OF MEDICAL CASE REPORTS, 14(1) [10.1186/s13256-020-02412-x].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/278186
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