Background: Immunological causes of parkinsonism are very rare and usually characterized by early presentation, poor response to levodopa, and additional clinical features. Case presentation: We describe a 58-year-old white man who presented with a 1-year history of gait disturbance with disequilibrium leading to falls. We report an association between parkinsonism and presence of anti-glutamic acid decarboxylase antibodies in his cerebrospinal fluid, discussing clinical presentation and follow-up. Conclusions: Besides the possibility of a casual association, this case allows us to hypothesize an alternative pathophysiological mechanism of parkinsonism implying interference with glutamic acid decarboxylase and gamma-aminobutyric acid functions, eventually resulting in basal ganglia circuit dysregulation.
Stefanoni, G., Formenti, A., Tremolizzo, L., Stabile, A., Appollonio, I., & Ferrarese, C. (2020). Atypical parkinsonism and intrathecal anti-glutamic acid decarboxylase antibodies - An unusual association: A case report. JOURNAL OF MEDICAL CASE REPORTS, 14(1) [10.1186/s13256-020-02412-x].
Citazione: | Stefanoni, G., Formenti, A., Tremolizzo, L., Stabile, A., Appollonio, I., & Ferrarese, C. (2020). Atypical parkinsonism and intrathecal anti-glutamic acid decarboxylase antibodies - An unusual association: A case report. JOURNAL OF MEDICAL CASE REPORTS, 14(1) [10.1186/s13256-020-02412-x]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Atypical parkinsonism and intrathecal anti-glutamic acid decarboxylase antibodies - An unusual association: A case report | |
Autori: | Stefanoni, G; Formenti, A; Tremolizzo, L; Stabile, A; Appollonio, I; Ferrarese, C | |
Autori: | ||
Data di pubblicazione: | 2020 | |
Lingua: | English | |
Rivista: | JOURNAL OF MEDICAL CASE REPORTS | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1186/s13256-020-02412-x | |
Appare nelle tipologie: | 01 - Articolo su rivista |