Purpose: Imaging manifestations of hepatic lymphoma, both primary (PHL) and secondary (SHL), are extremely variable and non-specific, but some features are useful diagnostic clues in an appropriate clinical setting. Through a PubMed search, we found several published reviews focused on PHL and SHL diagnosis. However, to the best of our knowledge, few of them encompass a comprehensive analysis of all the diagnostic tools and relative radiological findings. The aim of this review is to provide a description of the radiological features of both PHL and SHL, by critically analyzing the available literature. Materials and methods: An extensive review of published literature along with a description of personal case series of both PHL and SHL has been conducted. Results: SHL can be easily diagnosed with imaging techniques, as it is usually associated with node disease. On the contrary the diagnosis can be a challenge in PHL, often mimicking HCC or liver metastasis of adenocarcinoma. In this context, multiparametric MRI plays a fundamental role in the differential diagnosis. Both for PHL and SHL, liver involvement presents as solitary or multiple lesions or as diffuse infiltrative disease. Conclusion: PHL and SHL may be correctly characterized using different radiological techniques. Both CT and MRI have showed a good correlation with histology, as they permit to distinguish between lymphomatous tissue, and necrotic and fibrotic areas.

Ippolito, D., Porta, M., Maino, C., Pecorelli, A., Ragusi, M., Giandola, T., et al. (2020). Diagnostic approach in hepatic lymphoma: radiological imaging findings and literature review. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 146(6), 1545-1558 [10.1007/s00432-020-03205-x].

Diagnostic approach in hepatic lymphoma: radiological imaging findings and literature review

Ippolito D.;Porta M.;Maino C.;Pecorelli A.;Ragusi M.;Giandola T.;Querques G.;Talei Franzesi C.;Sironi S.
2020

Abstract

Purpose: Imaging manifestations of hepatic lymphoma, both primary (PHL) and secondary (SHL), are extremely variable and non-specific, but some features are useful diagnostic clues in an appropriate clinical setting. Through a PubMed search, we found several published reviews focused on PHL and SHL diagnosis. However, to the best of our knowledge, few of them encompass a comprehensive analysis of all the diagnostic tools and relative radiological findings. The aim of this review is to provide a description of the radiological features of both PHL and SHL, by critically analyzing the available literature. Materials and methods: An extensive review of published literature along with a description of personal case series of both PHL and SHL has been conducted. Results: SHL can be easily diagnosed with imaging techniques, as it is usually associated with node disease. On the contrary the diagnosis can be a challenge in PHL, often mimicking HCC or liver metastasis of adenocarcinoma. In this context, multiparametric MRI plays a fundamental role in the differential diagnosis. Both for PHL and SHL, liver involvement presents as solitary or multiple lesions or as diffuse infiltrative disease. Conclusion: PHL and SHL may be correctly characterized using different radiological techniques. Both CT and MRI have showed a good correlation with histology, as they permit to distinguish between lymphomatous tissue, and necrotic and fibrotic areas.
No
Articolo in rivista - Review Essay
Scientifica
Computed tomography; Magnetic resonance imaging; Primary hepatic lymphoma; Secondary hepatic lymphoma; Ultrasound; Female; Humans; Liver Neoplasms; Lymphoma; Male; Neoplasm Staging;
English
1545
1558
14
Ippolito, D., Porta, M., Maino, C., Pecorelli, A., Ragusi, M., Giandola, T., et al. (2020). Diagnostic approach in hepatic lymphoma: radiological imaging findings and literature review. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 146(6), 1545-1558 [10.1007/s00432-020-03205-x].
Ippolito, D; Porta, M; Maino, C; Pecorelli, A; Ragusi, M; Giandola, T; Querques, G; Talei Franzesi, C; Sironi, S
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/277882
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