Reactive Oxygen Species (ROS) play an essential dual role in living systems. Healthy levels of ROS modulate several signaling pathways, but at the same time, when they exceed normal physiological amounts, they work in the opposite direction, playing pivotal functions in the pathophysiology of multiple severe medical conditions (i.e., cancer, diabetes, neurodegenerative and cardiovascular diseases, and aging). Therefore, the research for methods to detect their levels via light-sensitive fluorescent probes has been extensively studied over the years. However, this is not the only link between light and ROS. In fact, the modulation of ROS mediated by light has been exploited already for a long time. In this review, we report the state of the art, as well as recent developments, in the field of photostimulation of oxidative stress, from photobiomodulation (PBM) mediated by naturally expressed light-sensitive proteins to the most recent optogenetic approaches, and finally, we describe the main methods of exogenous stimulation, in particular highlighting the new insights based on optically driven ROS modulation mediated by polymeric materials.

Antognazza, M., Abdel Aziz, I., Lodola, F. (2019). Use of exogenous and endogenous photomediators as efficient ROS modulation tools: Results and perspectives for therapeutic purposes. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019 [10.1155/2019/2867516].

Use of exogenous and endogenous photomediators as efficient ROS modulation tools: Results and perspectives for therapeutic purposes

Lodola F
Ultimo
2019

Abstract

Reactive Oxygen Species (ROS) play an essential dual role in living systems. Healthy levels of ROS modulate several signaling pathways, but at the same time, when they exceed normal physiological amounts, they work in the opposite direction, playing pivotal functions in the pathophysiology of multiple severe medical conditions (i.e., cancer, diabetes, neurodegenerative and cardiovascular diseases, and aging). Therefore, the research for methods to detect their levels via light-sensitive fluorescent probes has been extensively studied over the years. However, this is not the only link between light and ROS. In fact, the modulation of ROS mediated by light has been exploited already for a long time. In this review, we report the state of the art, as well as recent developments, in the field of photostimulation of oxidative stress, from photobiomodulation (PBM) mediated by naturally expressed light-sensitive proteins to the most recent optogenetic approaches, and finally, we describe the main methods of exogenous stimulation, in particular highlighting the new insights based on optically driven ROS modulation mediated by polymeric materials.
Articolo in rivista - Review Essay
Light Stimulation, ROS, Physiology
English
2019
2019
2867516
open
Antognazza, M., Abdel Aziz, I., Lodola, F. (2019). Use of exogenous and endogenous photomediators as efficient ROS modulation tools: Results and perspectives for therapeutic purposes. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019 [10.1155/2019/2867516].
File in questo prodotto:
File Dimensione Formato  
2019_Antognazza et al.pdf

accesso aperto

Dimensione 5.07 MB
Formato Adobe PDF
5.07 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/276347
Citazioni
  • Scopus 22
  • ???jsp.display-item.citation.isi??? 24
Social impact