The pathogenesis of the neurotoxicity of most antineoplastic drugs is unknown. Recent reports suggest that changes in the circulating levels of nerve growth factor (NGF) might be related to the dorsal root ganglia sensory neuron damage induced by cisplatin (CDDP), the first member of a family of widely used and very effective platinum-derived anticancer agents. Using a well-characterized model of CDDP neurotoxicity, we demonstrated that the NGF circulating level decreased during chronic CDDP administration in close accordance with the clinical course and returned to normal levels after recovery from the neurotoxic damage. Moreover, these changes were restricted to NGF and did not involve other trophic factors of the same neurotrophin family. Our findings are in agreement with previous in vitro and in vivo results and further suggest that NGF plays a specific role in the course of CDDP-induced primary sensory neuron damage. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Cavaletti, G., Pezzoni, G., Pisano, C., Oggioni, N., Sala, F., Zoia, C., et al. (2002). Cisplatin-induced peripheral neurotoxicity in rats reduces the circulating levels of nerve growth factor. NEUROSCIENCE LETTERS, 322(2), 103-106 [10.1016/S0304-3940(02)00091-5].

Cisplatin-induced peripheral neurotoxicity in rats reduces the circulating levels of nerve growth factor

CAVALETTI, GUIDO ANGELO;OGGIONI, NORBERTO;ZOIA, CHIARA PAOLA;FERRARESE, CARLO;MARMIROLI, PAOLA LORENA;TREDICI, GIOVANNI
2002

Abstract

The pathogenesis of the neurotoxicity of most antineoplastic drugs is unknown. Recent reports suggest that changes in the circulating levels of nerve growth factor (NGF) might be related to the dorsal root ganglia sensory neuron damage induced by cisplatin (CDDP), the first member of a family of widely used and very effective platinum-derived anticancer agents. Using a well-characterized model of CDDP neurotoxicity, we demonstrated that the NGF circulating level decreased during chronic CDDP administration in close accordance with the clinical course and returned to normal levels after recovery from the neurotoxic damage. Moreover, these changes were restricted to NGF and did not involve other trophic factors of the same neurotrophin family. Our findings are in agreement with previous in vitro and in vivo results and further suggest that NGF plays a specific role in the course of CDDP-induced primary sensory neuron damage. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Articolo in rivista - Articolo scientifico
cisplatin; nerve growth factor; toxicity; pathology; neurophysiology; neurotrophins
English
5-apr-2002
322
2
103
106
none
Cavaletti, G., Pezzoni, G., Pisano, C., Oggioni, N., Sala, F., Zoia, C., et al. (2002). Cisplatin-induced peripheral neurotoxicity in rats reduces the circulating levels of nerve growth factor. NEUROSCIENCE LETTERS, 322(2), 103-106 [10.1016/S0304-3940(02)00091-5].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/27634
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