Anti-sulfatide IgM antibodies have been recently associated with neuropathy but the clinical and electrophysiological correlations of this reactivity remains unclear. We reviewed the clinical and electrophysiological features of patients with high anti-sulfatide titers detected in our laboratory from 1991 to 1998. Of the 564 patients with different neurological diagnosis tested by enzyme-linked immunosorbent assay (ELISA), 11 had high anti-sulfatide IgM titers (>1/8000), 26 had titers of 1/8000 while 78 had titers of 1/4000. All patients with high anti-sulfatide IgM titers had a chronic, dysimmune, mostly sensorimotor neuropathy that in seven was associated with IgM monoclonal gammopathy. In most of these patients electrophysiological and morphological studies were consistent with a predominantly demyelinating neuropathy frequently associated with prominent axonal loss. Antibody titers of 1/8000, though always associated with neuropathy, did not correlate with a particular form or cause of neuropathy, while lower titers were equally distributed in patients with different neurological disorders. Our study indicate that high anti-sulfatide IgM titers (>1/8000) are highly predictive for a chronic, dysimmune, mostly demyelinating neuropathy often associated with IgM monoclonal gammopathy, and may therefore have potential diagnostic relevance.

Carpo, M., Meucci, N., Allaria, S., Marmiroli, P., Monaco, S., Toscano, A., et al. (2000). Anti-sulfatide IgM antibodies in peripheral neuropathy. JOURNAL OF THE NEUROLOGICAL SCIENCES, 176(2), 144-150 [10.1016/S0022-510X(00)00342-7].

Anti-sulfatide IgM antibodies in peripheral neuropathy

MARMIROLI, PAOLA LORENA;
2000

Abstract

Anti-sulfatide IgM antibodies have been recently associated with neuropathy but the clinical and electrophysiological correlations of this reactivity remains unclear. We reviewed the clinical and electrophysiological features of patients with high anti-sulfatide titers detected in our laboratory from 1991 to 1998. Of the 564 patients with different neurological diagnosis tested by enzyme-linked immunosorbent assay (ELISA), 11 had high anti-sulfatide IgM titers (>1/8000), 26 had titers of 1/8000 while 78 had titers of 1/4000. All patients with high anti-sulfatide IgM titers had a chronic, dysimmune, mostly sensorimotor neuropathy that in seven was associated with IgM monoclonal gammopathy. In most of these patients electrophysiological and morphological studies were consistent with a predominantly demyelinating neuropathy frequently associated with prominent axonal loss. Antibody titers of 1/8000, though always associated with neuropathy, did not correlate with a particular form or cause of neuropathy, while lower titers were equally distributed in patients with different neurological disorders. Our study indicate that high anti-sulfatide IgM titers (>1/8000) are highly predictive for a chronic, dysimmune, mostly demyelinating neuropathy often associated with IgM monoclonal gammopathy, and may therefore have potential diagnostic relevance.
Articolo in rivista - Articolo scientifico
Male; Neural Conduction; Middle Aged; Immunoglobulin M; Female; Peripheral Nervous System Diseases; Aged; Sulfoglycosphingolipids; Humans
English
144
150
Carpo, M., Meucci, N., Allaria, S., Marmiroli, P., Monaco, S., Toscano, A., et al. (2000). Anti-sulfatide IgM antibodies in peripheral neuropathy. JOURNAL OF THE NEUROLOGICAL SCIENCES, 176(2), 144-150 [10.1016/S0022-510X(00)00342-7].
Carpo, M; Meucci, N; Allaria, S; Marmiroli, P; Monaco, S; Toscano, A; Simonetti, S; Scarlato, G; Nobile Orazio, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/27577
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