Mutations in SCN5A, the gene coding for the human cardiac Na+ channel alpha-subunit, are associated with variant 3 of the long-QT syndrome (LQT-3). Several LQT-3 mutations promote a mode of Na+ channel gating in which a fraction of channels fail to inactivate, contributing sustained Na+ channel current (Isus), which can delay repolarization and prolong the QT interval. Here, we investigate the possibility that stimulation of protein kinase C (PKC) may modulate Isus, which is prominent in disease-related Na+ channel mutations.

Tateyama, M., Kurokawa, J., Terrenoire, C., Rivolta, I., & Kass, R. (2003). Stimulation of protein kinase C inhibits bursting in disease-linked mutant human cardiac sodium channels. CIRCULATION, 107(25), 3216-3222 [10.1161/01.CIR.0000070936.65183.97].

Stimulation of protein kinase C inhibits bursting in disease-linked mutant human cardiac sodium channels

Rivolta, I;
2003

Abstract

Mutations in SCN5A, the gene coding for the human cardiac Na+ channel alpha-subunit, are associated with variant 3 of the long-QT syndrome (LQT-3). Several LQT-3 mutations promote a mode of Na+ channel gating in which a fraction of channels fail to inactivate, contributing sustained Na+ channel current (Isus), which can delay repolarization and prolong the QT interval. Here, we investigate the possibility that stimulation of protein kinase C (PKC) may modulate Isus, which is prominent in disease-related Na+ channel mutations.
Articolo in rivista - Articolo scientifico
Scientifica
Ion Channel Gating; Animals; Sympathetic Nervous System; Humans; Enzyme Inhibitors; Mice; Muscle Cells; Diglycerides; Enzyme Activators; Structure-Activity Relationship; Sodium Channels; Sodium; Mutagenesis, Site-Directed; Protein Subunits; Mice, Mutant Strains; Patch-Clamp Techniques; Phosphorylation; Transfection; Cells, Cultured; Kidney; Long QT Syndrome; Protein Kinase C; Mutation; NAV1.5 Voltage-Gated Sodium Channel
English
Tateyama, M., Kurokawa, J., Terrenoire, C., Rivolta, I., & Kass, R. (2003). Stimulation of protein kinase C inhibits bursting in disease-linked mutant human cardiac sodium channels. CIRCULATION, 107(25), 3216-3222 [10.1161/01.CIR.0000070936.65183.97].
Tateyama, M; Kurokawa, J; Terrenoire, C; Rivolta, I; Kass, R
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/274359
Citazioni
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 23
Social impact