Sodium channels isolated from mammalian brain are composed of alpha-, beta(1)-, and beta(2)-subunits. The composition of sodium channels in cardiac muscle, however, has not been defined, and disagreement exists over which beta-subunits are expressed in the myocytes. Some investigators have demonstrated beta(1) expression in heart. Others have not detected any auxiliary subunits. On the basis of Northern blot analysis of total RNA, beta(2) expression has been thought to be exclusive to neurons and absent from cardiac muscle.

Malhotra, J., Chen, C., Rivolta, I., Abriel, H., Mattei, L., Brosius, F., et al. (2001). Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes. CIRCULATION, 103(9), 1303-1310 [10.1161/01.CIR.103.9.1303].

Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes

Rivolta, I;
2001

Abstract

Sodium channels isolated from mammalian brain are composed of alpha-, beta(1)-, and beta(2)-subunits. The composition of sodium channels in cardiac muscle, however, has not been defined, and disagreement exists over which beta-subunits are expressed in the myocytes. Some investigators have demonstrated beta(1) expression in heart. Others have not detected any auxiliary subunits. On the basis of Northern blot analysis of total RNA, beta(2) expression has been thought to be exclusive to neurons and absent from cardiac muscle.
Articolo in rivista - Articolo scientifico
Scientifica
Animals; Humans; Brain; Mice; Electrophysiology; Reverse Transcriptase Polymerase Chain Reaction; Sodium Channels; RNA, Messenger; Rats; Animals, Newborn; Antibody Specificity; Protein Subunits; Fluorescent Antibody Technique; Cell Line; Myocardium
English
Malhotra, J., Chen, C., Rivolta, I., Abriel, H., Mattei, L., Brosius, F., et al. (2001). Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes. CIRCULATION, 103(9), 1303-1310 [10.1161/01.CIR.103.9.1303].
Malhotra, J; Chen, C; Rivolta, I; Abriel, H; Mattei, L; Brosius, F; Kass, R; Isom, L
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/274349
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