Aim: Diabetic foot ulcers are the most common cause of nontraumatic lower extremity amputations in the industrialized world. Tissue-engineering products offer a lower extremity salvage strategy when healing does not proceed according to the standard of care. New allogeneic sheets are available for the management of diabetic leg and foot ulcers. Methods: The endpoints of this case series study regard preliminary outcomes of the application of allogeneic keratinocytes composed of benzyl ester of hyaluronic acid to 16 diabetic foot and leg ulcers in 11 patients with type 2 diabetes mellitus. Results: Between 21 and 70 days after cellular therapy, 6 out of 16 lesions were completely healed, reducing the wound dimension by 70% and improving the wound bed score by 52%. Conclusion: The clinical results of the new allogeneic sheets indicate that allogeneic keratinocytes may represent an effective and safe therapy for diabetic foot and leg ulcers in the multidisciplinary approach to this diabetes-related complication.

Marchesi, A., Marchesi, M., Parodi, P., Vaienti, L., Brambilla, R., Brioschi, M. (2014). Allogeneic epidermal substitutes in the treatment of chronic diabetic leg and foot ulcers. PASTIC AND AESTHETIC RESEARCH, 1(2), 74 [10.4103/2347-9264.139706].

Allogeneic epidermal substitutes in the treatment of chronic diabetic leg and foot ulcers

Marchesi, Matteo
Secondo
;
2014

Abstract

Aim: Diabetic foot ulcers are the most common cause of nontraumatic lower extremity amputations in the industrialized world. Tissue-engineering products offer a lower extremity salvage strategy when healing does not proceed according to the standard of care. New allogeneic sheets are available for the management of diabetic leg and foot ulcers. Methods: The endpoints of this case series study regard preliminary outcomes of the application of allogeneic keratinocytes composed of benzyl ester of hyaluronic acid to 16 diabetic foot and leg ulcers in 11 patients with type 2 diabetes mellitus. Results: Between 21 and 70 days after cellular therapy, 6 out of 16 lesions were completely healed, reducing the wound dimension by 70% and improving the wound bed score by 52%. Conclusion: The clinical results of the new allogeneic sheets indicate that allogeneic keratinocytes may represent an effective and safe therapy for diabetic foot and leg ulcers in the multidisciplinary approach to this diabetes-related complication.
Articolo in rivista - Articolo scientifico
Allogeneic keratinocytes, diabetic ulcer, epidermal substitutes, hyaluronic acid
English
2014
1
2
74
reserved
Marchesi, A., Marchesi, M., Parodi, P., Vaienti, L., Brambilla, R., Brioschi, M. (2014). Allogeneic epidermal substitutes in the treatment of chronic diabetic leg and foot ulcers. PASTIC AND AESTHETIC RESEARCH, 1(2), 74 [10.4103/2347-9264.139706].
File in questo prodotto:
File Dimensione Formato  
2014 Allogeneic epidermal substitutes in the treatment of chronic diabetic leg and foot ulcers.pdf

Solo gestori archivio

Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Dimensione 182.59 kB
Formato Adobe PDF
182.59 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/273977
Citazioni
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
Social impact